background: invasive fungal infections (ifis) are chief infectious complications in patients undergoing hematopoietic stem cell transplantation (hsct). however, the diagnosis of fungal infections is difficult, and often empiric treatment initiates. since there is no data available on the prevalence of antifungal drugs administration in allogeneic hsct recipients in iran, we decided to conduct t...

We examined whether mixed allogeneic transplantation with syngeneic plus allogeneic peripheral blood stem cells (PBSCs) is sufficient to interrupt autoimmune processes in BXSB mice and confer a potential therapeutic option for the treatment of patients with autoimmune diseases. Eight-week-old BXSB mice were lethally irradiated and reconstituted with BALB/c (H-2(d))+BXSB (H-2(b)) PBSCs, in which...

T cell responses to MHC-mismatched transplants can be mediated via direct recognition of allogeneic MHC molecules on the cells of the transplant or via recognition of allogeneic peptides presented on the surface of recipient APCs in recipient MHC molecules - a process known as indirect recognition. As CD4(+)CD25(+) Tregs play an important role in regulating alloresponses, we investigated whethe...

We performed a pilot study to test the effectiveness of allogeneic bone marrow transplantation in the treatment of chronic myelogenous leukemia. Five patients in the advanced stages of chronic myelogenous leukemia (four in blast crisis, one in accelerated phase) with abnormal chromosomes underwent matched-sibling allogeneic bone marrow transplantation after preparation with busulfan, vincristin...

BACKGROUND Allogeneic stem cell transplantation is associated with a powerful 'graft-versus-leukemia' effect that is generally considered to result from an alloreactive T-cell immune response. However, disease remission can also be observed after syngeneic transplantation and we investigated whether a T-cell immune response to cancer-testis antigens can be detected in patients in the post-trans...

Objective: Immune cells play important roles in mediating allograft rejection and tolerance after cardiac transplantation. However, immune cell heterogeneity at the single-cell level, how states shape transplantation immunity, remain incompletely characterized. Methods: We performed RNA sequencing (scRNA-seq) on LNs from a mouse syngeneic allogeneic model. Nine T clusters were identified throug...

1. De Renzo A, Pezzullo L, D'Arco A, et al. A five drug regimen (VEBEP) followed by involved field radiotherapy in the treatment of Hodgkin's disease [abstract]. Blood 1998; 92(Suppl. 1):235b (abs. 4009). 2. Flowers MED, Sullivan KM, Martin P, et al. G-CSF stimulated donor peripheral blood infusions as immunotherapy in patients with hematologic malignancies relapsing after allogeneic transplant...

Introduction: Paroxysmal nocturnal hemoglobinuria is a rare disease that presents with variety of symptoms including hematuria, thrombosis, and other non-specific symptoms. Venous thrombosis not uncommon in paroxysmal (PNH). However, thromboembolic event as the presenting symptom PNH can be life-threatening, when affects sagittal veins brain. Case Report: A 28-year-old female presented to facil...

The bone marrow failure states, aplastic anemia and myelodysplastic syndrome, are characterized by reticulocytopenic anemia, with variable neutropenia and thrombocytopenia. The bone marrow biopsy is very hypocellular in aplastic anemia, but it is usually hypercellular in myelodysplastic syndrome. Marrow cytogenetic abnormalities are present in approximately half of myelodysplastic syndrome pati...

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.