Studies of the apportionment of human genetic variation have long established that most human variation is within population groups and that the additional variation between population groups is small but greatest when comparing different continental populations. These studies often used Wright's F(ST) that apportions the standardized variance in allele frequencies within and between population...

CYP2C19 polymorphisms are important factors for proton pump inhibitor-based therapy. We examined the genotypes and analyzed distribution among ethnicities clinical outcomes in Indonesia. employed polymerase chain reaction-restriction fragment length polymorphism method to determine evaluated inflammation severity with updated Sydney system. For CYP2C19*2, 46.4% were homozygous wild-type allele,...

adult periodontitis is a complex multifactorial disease whose etiology is not well defined. the pro-inflammatory and bone resorption properties of interleukine-1α (il-1α) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. eighty iranian adult patients with periodontitis and 80 iranian controls were investigated in this study. in this study we report that the f...

We readwith great interest the recent paper byDonti et al. [1] on the diagnosis of adenylosuccinate lyase deficiency via plasma metabolomics. In their Supplementary Table S3, the authors provide the allele frequency for previously reported ADSLmutations. Based on this data, and adding the allele frequency of other pathogenic variants, one can estimate the minimal prevalence of the disease. The ...

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...