In the evolution of AIE-based drug and gene delivery systems, light-up AIEgens start in real-time monitoring processes evaluation therapeutic responses drug/gene; The delicate structural design to form high-level carriers remarkably enhances drug/gene efficiency; Further, endowed with multifunctionalities, are synergized multimodality therapy achieve augmented efficiency(e282).

growing amount of information on biological sequences has made application of statistical approaches necessary for modeling and estimation of their functions. in this paper, sensitivity and specificity of the first and second markov chains for prediction of genes was evaluated using the complete double stranded  dna virus. there were two approaches for prediction of each markov model parameter,...

Gene therapy has undergone a remarkable development in the last 20 years. Particularly important advances have been made in the improvement of gene transfer and expression technology, with current efforts focusing on the design of safer and long-term gene expression vectors as well as systems possessing cell-type specificity for transgene delivery and regulat‐ ability of its expression by small...

Human gene therapy holds great promise in treating not only hereditary genetic disorders, but also disease states such as cancer and viral infections, and contingencies such as stroke or myocardial infarctions. It can be achieved by delivery of a correct gene into target cells with genetic deficiency or mutations, or by transfer of a therapeutic agent such as agents targeting a cancer-causing o...

It has been over 40 years since I started biomaterials research. This article is a short summary of past research in my laboratory.

An extensive body of research using concurrent-chains schedules of reinforcement has shown that choice for one of two differentially valued food-associated stimuli is dependent upon the overall temporal context in which those stimuli are embedded. The present experiments examined whether the concurrent chains procedure was useful for the study of behavior maintained by alcohol and alcohol-assoc...

Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also make these nanoscaled materials highly interesting for the development of synthetic (non-viral) vectors for therapeutic nucleic acids. Rational...

Gene therapy bases its rationale on the transfer of genetic components (genes or fragments thereof) into somatic cells, with the aim of preventing, correcting, or healing various types of disorders. After this introductory sentence you expect us to start telling you some of the marvellous achievements in setting up the tools that allow this transfer. However, before entering into the intricate ...