Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15-70% of reported cases are fatal. There is no approved vaccine available, and preclinical protection in vivo by an experimental vaccine has not been demonstrated previously. In the present study, the attenuated poxvirus vector, Modified...

In 1964, D. H. Clarke defined two antigenic subtypes of Omsk haemorrhagic fever virus (OHFV) based on polyclonal antibody absorption and haemagglutination assays. The current report defines the molecular basis for these antigenic subtypes by comparison of the complete genomes of OHFV strains Kubrin (subtype I) and Bogoluvovska (subtype II). There were six nucleotide differences between these tw...

Haemorrhagic fever with renal syndrome (HFRS) has been described m a i n l y Y n í E i m Europe. Serological evidence of infection by Hantaan or a related virus has more recently been reported in Africa: in Gabon, only one of 30 sera examined was positive (GONZALEZ et al., 1984). In Senegal, SALUZ20 et al. (1985) reported a prevalence of 16.5% in inhabitants of Kabrousse, with 31% of tested rat...

To the editor: We thank Clement et al. for their interest in our work [1] and for questioning the diagnostic sequence and management of such a complex clinical and biological situation. During pregnancy, diagnosis of haemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses, including Seoul virus (SEOV), can easily be missed due to its rarity and its ‘pseudo-vasculoplacental’ clinica...

Dengue is acute viral disease transmitted to humans by Aedes mosquitoes (Ae. aegypti, Ae. albopictus). Dengue virus belongs to the family Flaviviridae, genus Flavivirus. There are four dengue virus serotypes (1-4) which are maintained endemically. The disease is endemic in tropical and subtropical areas between latitudes 35 degrees N and 35 degrees S. Infections may be asymptomatic or may produ...

Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne zoonotic disease. Over the past decade, CCHF cases in humans have emerged in Turkey and reemerged in the Balkan countries, Ukraine and Tajikistan. Occupational contact with infected livestock has been recognized as a common cause of the disease. A cross-sectional seroprevalence study in livestock was conducted in farming communities of an ...