Carbon-carbon bond cleavage/functionalization is synthetically valuable, and selective carbonyl-C(sp3 ) bond cleavage/alkynylation presents a new perspective in constructing ynamides, ynoates, and ynones. Reported here is the first alkoxyl-radical-enabled carbonyl-C(sp3 ) bond cleavage/alkynylation reaction by photoredox catalysis. The use of novel cyclic iodine(III) reagents are essential for ...

ALIPHATIC ALCOHOLS METHANOL, ETHANOL, 1-BUTANOL Eva Mračková Abstract: It is introduced the explosion Chamber VK 100 in the paper, in which we determined the lower explosive limits (LEL) of selected aliphatic alcohols as flammable liquids methanol, ethanol, 1-butanol. First, the calculations of the volume of flammable liquid necessary for setting of LEL were carried out. Next, it was carried ou...

The effect of alcohols (ethanol and methanol) on rat electromyogram (E.M.G.) and neuromuscular latency were studied in thiopentone anesthetized albino rats. Both alcohols were given intraperitoneally (100 mg/100 g of body weight) to the respective groups and the controls received saline. Electromyographic signals were recorded from gastrocnemius muscle. For latency studies both the alcohols wer...

An atom-economical diastereoselective synthesis of indenodithiepines and indenodithiocines has been developed via a domino reaction of propargylic alcohols and dithioacetals in the presence of InCl3 as a catalyst. A range of functionalized dithiepines and dithiocines, fused to the indene ring, were obtained in good to excellent yields under mild conditions.

A highly enantioselective synthesis of homopropargylic alcohols is achieved by using the new helical chiral 2,2'-bipyridine N-monoxide catalyst and allenyltrichlorosilane. This method can be further extended to the enantio- and regioselective propargylation of N-acylhydrazones.

A catalytic system consisting of the ruthenium(II) complex [Ru(η³-2-C3H4Me)(CO)(dppf)][SbF6] (dppf=1,1'-bis(diphenylphosphino)ferrocene) and trifluoroacetic acid has been used to promote the coupling of secondary propargylic alcohols with 6-chloro-4-hydroxychromen-2-one. The reactions afforded unusual 2-methylene-2,3-dihydrofuro[3,2-c]chromen-2-ones in good yields.

We have developed catalytic allylation reactions of sulfonylimidates using allylic alcohols as allylating reagents. Stoichiometric amounts of neither activators nor bases are required in this reaction.

Although considerable work has been done on the formation of acetylmethylcarbinol by Aerobacter, except for the work of Koser (1918), O'Meara (1931), and Reynolds and Werkman (1937a,b), those studies employing cultures of growing cells were done in complex, chemically undefined media which tend to obscure the underlying chemical reaction. In the present study, intact, washed Aerobacter cells we...

Highly sensitive chiral labeling reagents, (1R,2R)- and (1S,2S)-2-(2,3-anthracenedicarboximido)cyclohexanecarboxylic acids [(1R,2R)- and (1S,2S)-A] and (1R,2R)- and (1S,2S)-2-(2,3-naphthalenedicarboximido)cyclohexanecarboxylic acids [(1R,2R)- and (1S,2S)-A'], were prepared. Reagent A has enabled us to discriminate the enantiomers of anteiso fatty alcohols up to C9 methyl branching by 1H NMR, an...

A novel and efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base has been developed. The protocol uses readily available acrylic derivatives and primary alcohols as the starting materials, inexpensive CuCl(2) as the catalyst, and the corresponding addition products were obtained in moderate to excellent yields.