Hepatitis B virus (HBV) is a non-cytopathic virus that causes acute and chronic inflammatory liver diseases, often leading to the pathogenesis of hepatocellular carcinoma (HCC). Although many studies for the roles of HBV on pathogenesis of the liver diseases, such as non-alcoholic fatty liver disease (NAFLD), hepatic inflammation, cirrhosis, and HCC, have been reported, the mechanisms are not f...

background: non-alcoholic fatty liver disease (nafld) was one of prevalent problems in general population. it was the most common cause of abnormal liver function tests and may lead to steatohepatitis and cirrhosis. the role of many factors has been known in nafld. in this study, we investigated the correlation of serum magnesium level and nafld after minimizing the role of major confounding fa...

introduction: non-alcoholic fatty liver disease (nafld) has become the most common cause of liver disease worldwide. it has been suggested that dietary composition plays a role in nafld pathogenesis; thus, changing dietary patterns may constitute a therapeutic resource even in the absence of weight reduction. the aim of this study was to identify the characteristic of suitable dietary pattern i...

The gut microbiota has recently evolved as a new important player in the pathophysiology of many intestinal and extraintestinal diseases. The liver is the organ which is in closest contact with the intestinal tract, and is exposed to a substantial amount of bacterial components and metabolites. Various liver disorders such as alcoholic liver disease, non-alcoholic liver disease and primary scle...

Serum aspartate aminotransferase isoenzymes were measured in 123 hospital patients with various liver diseases, using a new and simple immunochemical method. Our findings show the usefulness of this determination in estimating the severity of hepatic damage, especially if accompanied by the measurement of other mitochondrial enzymes. During hepatic damage, the cytoplasmic isoenzyme is found in ...

Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis and hepatocellular carcinoma, because of its antioxidant, anti-inflammatory and antifibrotic power. Indeed, the anti-oxidant and anti-inflammatory effect of silym...

background: alcoholic mothers who consume ethanol give birth to infants with high percentage of hepatic diseases. alcohol can cause cellular damage in different tissues, including liver. finding a drug which is effective and efficient in reducing ethanol misuse consequences during pregnancy can assist the decrease of harmful effects of this habit. objective: this research aims to study the effe...

Diabetes mellitus, pathoglycemia, dyslipidemia, non-alcoholic fatty liver, overweight, hypertension, and atherosclerosis are common diseases endangering human health. Cachexia is a life-threatening disease condition. associated with increased mortality. Cancer patients cachexia less tolerant have decreased response to chemotherapy radiation. Do these pathogenesis? We will discuss the commonalit...

Ethanol impairs immune responses in humans and animal models, in vivo and in vitro. In particular, ethanol inhibits some key functions of human polymorphonuclear neutrophils (PMN). We investigated the impact of ethanol on cytokine production by highly purified PMN. In a time- and concentration-dependent manner, ethanol inhibited the production of interleukin (IL)-8 protein and mRNA and also hin...

BACKGROUND Obstructive sleep apnea is a common disorder acting as a risk factor for the development and progression of cardiometabolic derangements including non-alcoholic fatty liver disease. Recent research data suggest that non-alcoholic fatty pancreatic disease may be a more sensitive marker than non-alcoholic fatty liver disease for early subclinical metabolic risk and may contribute to th...