The effect of an intravitreal injection of NMDA on the expression of brain-derived neurotrophic factor (BDNF) in retinal ganglion cells was investigated in rats. Forty-eight hours after intravitreal injection of NMDA retinal ganglion cell BDNF immunoreactivity was practically obliterated, as was the choline acetyltransferase (ChAT) immunoreactivity associated with a subset of amacrine cells. Ho...

MOST hepatic functions are genetically determined and. after liver transplantation. the hepatic parenchyma retains its species specificity. Therefore. in the hamster-to-rat liver xenotransplantation mode!.' we assessed the phenotypic changes of the serum protein profile in the recipient. as well as the functional compatibility between the xenoproteins and the recipient environment. Upon serum p...

DNA lesions, cytotoxicity, and cellular uptake of CaCrO4 were compared in Chinese hamster ovary, in mouse embryo fibroblast C3H10T1/2, and in human osteosarcoma cells. The concentration of CaCrO4 that reduced colony formation by 50% was 2- or 3-fold less in human osteosarcoma cells than in C3H10T1/2 or Chinese hamster ovary cells. Alkaline elution studies showed that CaCrO4 induced DNA single s...

Early monocular enucleations were done in rats, either at embryonic day 16 (E16) or on the day of birth, and the surviving uncrossed pathway was studied either at birth for some of the animals enucleated prenatally, or in the adult for all of the other animals. The uncrossed pathways were studied by using HRP as a retrograde tracer. The neonatal enucleations showed the increase of the surviving...

than do human and rat liver, and hamster-derived cells in culture express more enzyme than do lines derived from tissues of other animals (18). This report describes the purification of 2 major glutathione S-transferase forms from hamster liver and a comparison of the properties of the forms with those from human and rat liver. The data suggest that certain fundamental differences between the h...

Hamster cells which transformed after exposure to herpes simplex virus type 2 previously irradiated with ultraviolet light were tested for the presence of hamster leukosis viruses or their virus-specific antigens. Three techniques that were used did not detect the presence of either hamster C-type particles or antigens commonly associated with such structures. The implication of these findings ...

Cytoplasmic retinoic acid binding protein (cRABP) is present in human fetal pancreas and becomes nondetectable in the normal adult pancreas. The binding protein for retinoic acid becomes apparent again in pancreatic cancer. Similar fluctuations in the content of cRABP occur in the hamster. The binding protein is undetectable in the normal adult hamster pancreas, while it was detected in several...

A narcotic or a non-narcotic analgesic that would not cause respiratory depression and addiction in may be used as an alternative to morphine. In Ayurveda a large number of indigenous drugs have been mentioned possessing the analgesic properties e.g Guggul, Erand, Rasna, Bhringaraja, Methika, palandu and prasikayavani. Total alcoholic extracts of Bhringaraja (Eclipta alba) was undertaken to stu...

The intraocular pressure of imperfect albino mutant quails with a sex-linked recessive gene was measured by using a cannulating method, and morphological changes of the iridocorneal angle were observed with a gonioprism. Albino mutant quails were characterized by an elevated intraocular pressure and lens enlargement at 6 mo after hatching. Initially the iridocorneal angle opened and eventually ...

To investigate the immunomodulatory activity of flavonoid fractions of Terminalia catappa in Swiss albino mice. The flavonoid fraction of T.catappa was administrated intraperitonealy at a dose of ED50 to healthy albino mice. Assessment of immunomodulatory activity was carried out by assessment of neutrophil adhesion and phagocytic index. Intraperitonealy administered Tcff showed a significant i...