CONTEXT  Allanblackia floribunda Oliver (Guttiferae) is an African medicinal plant used traditionally to treat a variety of ailments. OBJECTIVE  We investigated the antitumor, radical scavenging, antimycobacterial, antibacterial and antifungal activities of the root bark extract of A. floribunda and three isolated phenolics, namely 1,7-dihydroxyxanthone (1), morelloflavone (2) and 7'-O-glucos...

BACKGROUND Tubulointerstitial fibrosis is a relatively common and sinister complication of cyclosporine A (CsA) therapy that limits its clinical use. CsA may have direct effects on renal tubular epithelial cells by promoting epithelial-mesenchymal transition (EMT). EMT plays an important role in embryonic development and tumourigenesis and has been described in organ remodelling during fibrogen...

Oral cancer (OC) is one of the 10 most diagnosed cancers in the world. It is aggressive and difficult to treat. Despite the achieved therapeutic advances, the 5 year survival rate has not changed in the past decade. Understanding the basic molecular pathogenesis of OC may give new opportunities for future treatments. Regulators of the immune system such as CD40 [1]. and CD26 [2] are believed to...

BACKGROUND To explore and analyse the association between biofilm and the genetic polymorphisms of scrA gene of EnzymeIIscr found in clinical isolates of Streptococcus mutans (S. mutans) from severe early childhood caries (S-ECC) in 3 years old children. METHODS Clinical strains of S. mutans were conserved from a previous study. Thirty strains of S. mutans from the S-ECC group and 30 strains ...