Alüminyum döküm ala??mlar?; hafifletme, enerji tasarrufu, geri dönü?üm ve çevre duyarl?l??? gibi ülkemizin Dünya’n?n öncelikli çal??ma alanlar?nda yer alan konular göz önüne al?nd???nda, endüstrinin gözde ala??m grubunu temsil etmektedir. Son y?llarda ba?ta otomotiv ana yan sanayisi olmak üzere, havac?l?k, uçak uzay endüstrisinde kullan?m alanlar?n?n artmas?yla, alüminyum ala??mlar?n?n sahip ol...

BACKGROUND: Titanium dioxide nanoparticles (TiO2 NPs) uptake may primarily cause adverse effects by inducing oxidative stress, resulting in cell damage, genotoxicity, inflammation, and immune response. To date, there are limited studies investigating the effect of TiO2 NPs on liver health no found a naturally occurring compound able to ameliorate such effect. Thus, this study investigated alpha...

Ionizing irradiation is a well‑established therapeutic modality for malignant gliomas. Due to its high cellular uptake, 5‑aminolevulinic acid (ALA) is used for fluorescence‑guided resection of malignant gliomas. We have previously shown that 5‑ALA sensitizes glioma cells to irradiation in vitro. The aim of the present study was to assess whether 5‑ALA acts as a radiosensitizer in experimental g...

Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity. Recently, it has been suggested that alpha lipoic acid (ALA) improves insulin sensitivity by lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle AMP-activated protein kinase (AMPK). We examined whether chronic ALA supplementation prevents muscular lipid accumulation...

BACKGROUND The composition of dietary fatty acids (FA) during early life may impact adult adipose tissue (AT) development. We investigated the effects of alpha-linolenic acid (ALA) intake during the suckling/weaning period on AT development and metabolic markers in the guinea pig (GP). METHODS Newborn GP were fed a 27%-fat diet (w/w %) with high (10%-ALA group), moderate (2.4%-ALA group) or l...

Vancomycin resistance in Gram-positive bacteria is due to production of cell-wall precursors ending in D-Ala-D-Lac or D-Ala-D-Ser, to which vancomycin exhibits low binding affinities, and to the elimination of the high-affinity precursors ending in D-Ala-D-Ala. Depletion of the susceptible high-affinity precursors is catalyzed by the zinc-dependent D,D-peptidases VanX and VanY acting on dipepti...

Background and Objectives: Alpha-lipoic acid (ALA) is considered as a potent antioxidant with anti-inflammatory functions. Moreover, a number of studies have revealed its lipid lowering properties. Therefore, we aimed to examine the effect of ALA on serum lipids in women with rheumatoid arthritis (RA), who have high mortality rate mainly due to accelerated atherosclerosis. Materials and Method...

Background: Arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. The present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ALA) against such hematological disorders.Methods: Twenty-four adult male Wister rats (b.wt.130±10g) wer...

Equilibrium adsorption of gas phase mixtures of Dand Lalanine (Ala) onto the naturally chiral Cu{3,1,17} surfaces has been studied by both experiment and DFT-based modeling. Isotopically labeled *L-Ala (HO2 CCH(NH2)CH3) and unlabeled D-Ala allow mass spectrometric enantiodifferentiation of the adsorbed species during temperature-programmed decomposition, following equilibrium adsorption. Measur...