Regarding our article on the association of androgen deprivation therapy (ADT) with increased Alzheimer’s disease risk, Bowen et al, Froehner and Wirth, Leow et al, and Brady et al highlight a number of significant considerations that will prove important in the design of future studies that investigate the association of ADT and Alzheimer’s disease. We agree with Bowen et al and Leow et al tha...

The science of interpretation has a special position in the Islamic sciences and has been addressed seriously by Muslims from the very first days of Islam, because interpretation is to understand and discover the points of the best speech, i.e. the speech of the Sublime Allāh. One of the new commentaries on Muslims' divine book is al-Tafsīr al-munīr fī al-‘aqīda wa al-sharī‘a wa al-munhaj, auth...

The antiviral RNA-dependent protein kinase, PKR, binds to viral double-stranded RNA in the cell and halts protein synthesis by phosphorylating the alpha subunit of the translation initiation factor eIF2. In this issue of Cell, two complementary papers Dar et al. (2005) and Dey et al. (2005) address the interaction between PKR and eIF2alpha. The structures of eIF2alpha bound to PKR reveal that P...