Sepsis is the main cause of acute kidney injury (AKI), mainly due to systemic immune dysregulation. Kaempferol (KAE) a natural flavonoid compound with multiple biological activities including anti-inflammatory, antioxidant, and antiapoptotic properties. In this study, we constructed sepsis-induced AKI mouse model an LPS-induced glomerular mesangial cell (HK-2) in vitro sepsis model. We found th...

Abstract Tumor Treating Fields (TTFields) are alternating electric fields, which disrupt cellular process critical for cancer cell survival and tumor progression. TTFields therapy is approved the treatment of glioblastoma (GBM) unresectable malignant pleural mesothelioma, being tested in clinical studies other solid tumors, including ovarian cancer, non-small lung carcinoma (NSCLC), hepatocellu...

Purpose: Alzheimer’s disease (AD) is a common in the world caused by deposition brain parenchyma, accumulation of beta amyloid which leads to blood barrier (BBB) disruption. Regardless enough progress treatment AD, principal mechanism BBB injury yet not clear.Methods: In this study we examined impact EGb761on Aβ 1-42-induced SH-SY5Y cells vitro model AD. Cell viability was assessed using MTT as...

Abstract Objective We aimed to investigate the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction rat bone marrow mesenchymal stem cells (BMSCs) following peroxidative damage and explore underlying mechanisms. Methods Conditioned medium was used induce differentiation BMSCs, which were treated with H 2 O , extracts-containing serum, or phosphatidyl inositol-3 kinase (...

AKT serine threonine kinase of the protein kinase B (PKB) family plays essential roles in cell survival, growth, metabolism, and differentiation. In the erythroid system, AKT is known to be rapidly phosphorylated and activated in response to erythropoietin (Epo) engagement of Epo receptor (EpoR) and to sustain survival signals in cultured erythroid cells. Here we demonstrate that activated AKT ...

The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself. It was previously reported that Akt phosphorylates the mTORC2 subunit SIN1 at T86, activating mTORC2 through a positive feedback loop, though another study reported that S6K phos...

The phosphoinositide 3-kinase/Akt pathway is thought to be essential for normal insulin action and glucose metabolism in skeletal muscle and has been shown to be dysregulated in insulin resistance. However, the specific roles of and signaling pathways triggered by Akt isoforms have not been fully assessed in muscle in vivo. We overexpressed constitutively active (ca-) Akt-1 or Akt-2 constructs ...

İklim değişikliğinin etkisinin en fazla hissedileceği bölgelerden biri olan Akdeniz havzasında bulunan ülkemizde gelecekte ortaya çıkabilecek önemli sorunlardan birisi de su kaynaklarının miktar ve kalitesi ile ilgilidir. Su stresi yaşayan ülkemizin değişen iklim koşullarına karşı var kaynaklarını sürdürülebilir bir planlama çerçevesinde kullanması gerekmektedir. Bu nedenledir ki suyun kalite r...

Insulin and insulin-like growth factor stimulate protein synthesis cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) signalling via kinase B (PKB, also known as Akt). Protein is increased hearts perfused at alkaline pHo to same extent with insulin. Moreover, ?1-adrenergic receptor (?1-AR) agonists (e.g. phenylephrine) increase cardiomyocytes, activating PKB/Akt. In b...

Pancreatic ductal adenocarcinoma (PDAC) is a growing cause of cancer-related mortality worldwide. Kallikrein-related peptidase 8 (KLK8) has potential clinical values in many cancers. However, the clinicopathological significances KLK8 PDAC remain unknown. We explored relationship to features based on public databases. expression was examined human tissues. Cell proliferation and apoptosis were ...