نتایج جستجو برای: airway clearance

تعداد نتایج: 130511  

Journal: :Cold Spring Harbor perspectives in medicine 2013
Brenda M Button Brian Button

In cystic fibrosis (CF), a defect in ion transport results in thick and dehydrated airway mucus, which is difficult to clear, making such patients prone to chronic inflammation and bacterial infections. Physiotherapy using a variety of airway clearance techniques (ACTs) represents a key treatment regime by helping clear the airways of thickened, adhered, mucus and, thus, reducing the impact of ...

Journal: :Cell 1998
Hirotoshi Matsui Barbara R Grubb Robert Tarran Scott H Randell John T Gatzy C.William Davis Richard C Boucher

The pathogenesis of cystic fibrosis (CF) airways infection is unknown. Two hypotheses, "hypotonic [low salt]/defensin" and "isotonic volume transport/mucus clearance," attempt to link defects in cystic fibrosis transmembrane conductance regulator-mediated ion transport to CF airways disease. We tested these hypotheses with planar and cylindrical culture models and found no evidence that the liq...

2013
Garry M Walsh

Asthma is an increasingly common respiratory condition characterized by reversible airway obstruction, bronchial hyper-responsiveness and airway inflammation with a clear unmet need for more effective therapy. Eosinophilic asthma is a phenotype of the condition that features increased blood or sputum eosinophils whose numbers correlate with disease severity. Several lines of evidence are now em...

2011
Stephan A. Carey

Chronic bronchitis (CB) is the most common chronic respiratory impairment in dogs. The condition is defined as a chronic cough occurring for two consecutive months during the preceding year that is not attributable to another cause (e.g. neoplasia, congestive heart failure). This definition is based loosely on the definition of chronic bronchitis in humans, which is characterized by a well-defi...

Journal: :The European respiratory journal 2015
Susanne Herold Christin Becker Karen M Ridge G R Scott Budinger

The influenza viruses are some of the most important human pathogens, causing substantial seasonal and pandemic morbidity and mortality. In humans, infection of the lower respiratory tract of can result in flooding of the alveolar compartment, development of acute respiratory distress syndrome and death from respiratory failure. Influenza-mediated damage of the airway, alveolar epithelium and a...

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