Acylhomoserine lactone (AHL) synthases act as chemical communication signals or pheromones in Gram-negative bacteria and regulate diverse physiological events in a cell density-dependent manner. The recent crystal structure determination of EsaI, a key enzyme in this pathway, shows that the AHL synthase superfamily members adopt the fold of the N-acetyltransferase superfamily. We suggest, by th...

despite the great fame the well-known abbasid poet –abu nuwas- enjoys, his real character is covered in a misty cloud. one of the vague aspects of his character is his religious and political tendency in a way that his poems carry the features of both atheism and belief in god and the judgment day. from a political perspective, he is an advocate of abbasid government, and at the same time a shi...

The Lhcp constituents of the photosynthetic apparatus of higher plants form protein-pigment complexes that are involved in the capture and distribution of light energy in both photosystems in the thylakoid membranes (Anderson, 1986). Severa1 Lhcps encoded by multigene families and closely related on a structural basis are found in each plant species (Buetow et al., 1988). Sequences for Lhcp gen...

Despite long-term efforts to elucidate the mechanisms responsible for age-related hearing loss (AHL), there is currently no available treatment strategy able to provide a cure. Apoptotic cell death, including that of hair cells and spiral ganglion neurons (SGNs) in the cochlea has been proposed to be the classic theory behind the development of AHL. As calcium signaling plays key roles in signa...

The rTSbeta protein has been hypothesized to synthesize signaling molecules that can down-regulate thymidylate synthase. These molecules share biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might act as rTS signaling mimics and down-regulate thymidylate synthase. We have determined that the AHL, 3-oxododecanoyl homoserine lactone (3-oxo-C12-(L)-HSL)...

The effects aging of digital circuits are came into the focused due to observations made with several experiments and researchers has start working towards making changes for the improvements in base paper architecture. The integrated device suffers with NBTI and PBTI due to CMOS semiconductor properties and it affects the working of different logic operations and in the same context here we ha...

One defining goal of synthetic biology is the development of engineering-based approaches that enable the construction of gene-regulatory networks according to design specs generated from computational modeling. This has resulted in the construction of several fundamental gene circuits, such as toggle switches and oscillators, which have been applied in novel contexts such as triggered biolm de...

Pseudomonas aeruginosa plays a major role in many chronic infections. Its ability to readily form biofilms contributes to its success as an opportunistic pathogen and its resistance/tolerance to antimicrobial/antibiotic therapy. A low molecular weight alginate oligomer (OligoG CF-5/20), derived from marine algae, has previously been shown to impair motility in P. aeruginosa biofilms and disrupt...