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Staphylococcus aureus strains lacking agr- and sarA-dependent gene products or specific MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesins were compared for the ability to activate inflammatory responses in the lung. The mutants were evaluated for virulence in a mouse model of pneumonia and by quantifying their ability to stimulate interleukin-8 (IL-8) and gra...

Immunotherapy offers survival benefits for patients with advanced gastric cancer, but not all populations can benefit from immunotherapy. Good nutritional status is fundamental to a patient's immune function and may have an impact on the efficacy of The present study aimed investigate changes in prognostic index (PNI), lung cancer inflammation (ALI) albumin‑globulin ratio (AGR) values before af...

INTRODUCTION Hypertension (HTN) and diabetes mellitus (DM) are two common non-communicable diseases (NCDs) that are closely linked: one cannot be properly managed without attention to the other. The aim of this study was to determine the prevalence of undiagnosed diabetic and pre-diabetic states that is abnormal glucose regulation (AGR) and factors associated with it among hypertensive patients...

Three to four hundred new or renovated turfgrass systems are constructed in the U.S. each year. Many of these systems (golf courses, city parks, and residential and institutional lawns) are constructed in agricultural and silvicultural environments. However, knowledge of the water quality impact in transitioning from an agricultural or silvicultural landscape to a turfgrass landscape is at best...

This paper presents an extension of the AGR (Agent-GroupRole) organizational model, called AGRE (AGR + Environment), which includes physical (or simply geometrical) environments. This extension is based on the concept of a space which can be seen either as a physical area or as a social group, and on a clear distinction between an agent and its mode, i.e. the way it appears and interacts into a...

We investigated the impacts of sarA and agr on fnbA expression and fibronectin-binding capacity in Staphylococcus aureus in vitro and in experimental endocarditis. Although sarA up-regulated and agr down-regulated both fnbA expression and fibronectin binding in vitro and in vivo, fnbA expression was positively regulated in the absence of both global regulators. Thus, additional regulatory loci ...

Staphylococcal superantigen-like (SSL) proteins, which are encoded by a cluster of eleven ssl genes, contribute to the Staphylococcus aureus virulence. Recently we reported ssl8 expression profiles in seven clinically important strains-MW2, USA300FPR3757, MSSA476, Newman, RN6390, Mu50, and N315-and showed the differential expression of ssl8 in Newman, RN6390, and USA300FPR3757 strains, despite ...