background: to compare a flexible, multi-dose gnrh antagonist protocol with a long gnrh .agonist protocol in poor respo materials and methods: a randomized clinical trial of 70 poor responder patients (35 patients in gnrh antagonist protocol and 35 patients in long gnrh agonist protocol) was performed at royan institute, tehran, iran. both groups were given a fixed dose of human menopausal gona...

The objective of the present study was to assess the role of the 5-HT2A/2C receptor at two specific brain sites, i.e., the dorsal periaqueductal gray matter (DPAG) and the medial septal (MS) area, in maternal aggressive behavior after the microinjection of either a 5-HT2A/2C receptor agonist or antagonist. Female Wistar rats were microinjected on the 7th postpartum day with the selective agonis...

Tuo, Bi-Guang, Zachary Sellers, Petra Paulus, Kim E. Barrett, and Jon I. Isenberg. 5-HT induces duodenal mucosal bicarbonate secretion via cAMPand Ca -dependent signaling pathways and 5-HT4 receptors in mice. Am J Physiol Gastrointest Liver Physiol 286: G444–G451, 2004. First published October 23, 2003; 10.1152/ ajpgi.00105.2003.—In previous studies, we have found that 5-hydroxytryptamine (5-HT...

objective: coasting can reduce the ovarian hyperstimulation syndrome (ohss) risk in ovulation induction cycles before intracytoplasmic sperm injection (icsi). this study aimed to investigate the effect of gonadotropin-releasing hormone (gnrh) agonist and gnrh antagonist protocols to controlled ovarian hyperstimulation (coh) cycles with coasting on the parameters of icsi cycles and the outcome. ...

The ligand binding and G-protein coupling of the bovine hippocampal 5-HT1A receptor as a function of temperature was monitored. There is an almost complete and irreversible loss in agonist binding at 50 degrees C. However, the antagonist binding is reduced only by 50%, and this could be reversed if the temperature is lowered to 25 degrees C. Interestingly, the agonist binding of the 5-HT1A rece...

Atypical antipsychotic drugs, which are distinguished from typical antipsychotic drugs by a lower incidence of extra-pyramidal side effects and less propensity to elevate serum prolactin levels (e.g., clozapine, olanzapine, risperidone, quetiapine, ziprasidone), have become the most widely used treatments for schizophrenia, although their precise mechanism of action remains controversial. It ha...

In previous studies, we have found that 5-hydroxytryptamine (5-HT) is a potent stimulant of duodenal mucosal bicarbonate secretion (DMBS) in mice. The aim of the present study was to determine the intracellular signaling pathways and 5-HT receptor subtypes involved in 5-HT-induced DMBS. Bicarbonate secretion by murine duodenal mucosa was examined in vitro in Ussing chambers. 5-HT receptor invol...

In the present study we found that repeated co-treatment with fluoxetine and amantadine for 14 days (but not for 7 days) enhanced the hyperactivity induced by amphetamine or quinpirole (a dopamine D(2/3) agonist), compared to treatment with either drug alone. Whereas repeated co-treatment with fluoxetine and amantadine for 7 days more potently inhibited the behavioral syndrome evoked by the 5-h...

the plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is assessment the effects of ca1 5-ht4 receptor on memory acquisition deficit induced by harmaline. harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs67333) and antagonist (rs23597-...