Reversing the field Do terrestrial geomagnetic reversals have an effect on Earth's climate? Cooper et al. created a precisely dated radiocarbon record around time of Laschamps reversal about 41,000 years ago from rings New Zealand swamp kauri trees. This reveals substantial increase in carbon-14 content atmosphere culminating during period weakening magnetic strength preceding polarity switch. ...

Journal of Psychiatry) casually threw out) casually threw out the suggestion that I might write a column the suggestion that I might write a column for the journal similar to one entitled for the journal similar to one entitled 'One Hundred Years Ago', occasionally 'One Hundred Years Ago', occasionally published in the published in the BMJ BMJ. I was immediately in-. I was immediately intrigued...

Twenty-five years ago, in December 1988, my research group at Caltech submitted the world’s first asynchronous (“clockless”) microprocessor design for fabrication to MOSIS. We received the chips in early 1989; testing started in February 1989. The chips were found fully functional on first silicon. The results were presented at the Decennial Caltech VLSI Conference in March of the same year. Th...

I was appointed house physician at The Hospital for Sick Children in 1937. In retrospect I can see that I was there at a very particular time in the hospital's history, because 1937 was to mark the end of an era. A decade or so before, the fame of Great Ormond Street had depended on a generation of physicians of the calibre of Still, Garrod, Batten, and Poynton. But the staffing of the hospital...

agitation which followed the redaction of several administrative appointments in the I. M. S. in 1880, and the indignation caused among the senior officers by some of the promotions which followed thereon. The amalgamation of the military medical administration of the A. M. D. and of the I. M. S. in India, which had previously been carried on by a double set of officers, one from each service, ...

Argonaute (Ago) proteins are key players of nucleic acid-based interference mechanisms. Their domains and structural organization are widely conserved in all three domains of life. However, different Ago proteins display various substrate preferences. While some Ago proteins are able to use several substrates, others are limited to a single one. Thereby, they were demonstrated to act specifical...