MDMA causes selective depletion of serotonergic terminals in experimental animals and the consequent decrease in synaptic 5-HT may, inter alia, increase impulsivity. To study the effects of MDMA upon brain function, the behaviour of male Dark Agouti rats exposed to MDMA (15 mg/kg i.p.), two 5-HT1B agonists (CGS-12066A and CP-94,253, both 5 mg/kg i.p.) or saline were investigated in the resident...

Twelve patients with personality disorders or chronic schizophrenia in whom aggressive-destructive behaviour was a prominent feature were treated by bilateral stereotaxic electrocoagulation of the amygdala. In two of the patients a cingulectomy and in five of the patients a frontal lobotomy had been performed several years previously without effect. In 11 of the patients the amygdalotomy result...

PURPOSE This study examines risk factors for aggression among boys in Kingston, Jamaica. METHODS One hundred and one aggressive and 101 prosocial schoolboys in grades 5-6 (mean age 11.7, SD 0.6 years) were selected by peer and teacher ratings from 10 schools in the capital city, Kingston, during 1998. They were given in-depth questionnaires, arithmetic, reading and verbal intelligence tests a...

The effects of wisanine and dihydrowisanine were studied on stereotyped and aggressive behaviour induced by apomorphine (0.5 mg/kg s.c.) in chicks. Pretreatment of chicks with wisanine (0.3-0.6 g/kg i.p.) and dihydrowisanine (0.2-0.4 g/kg i.p.) dose dependently antagonised fighting episodes and pecking of the chick's own feet and those of other chicks. It has been suggested that the antagonism ...

THE TREATMENT OF VIOLENT BEHAVIOUR PROBLEMS OVER THE LAST TWO decades has increasingly utilised a cognitive-behavioural approach. Relapse Prevention (RP) (Marlatt & Gordon 1985) is a variety of cognitive-behavioural intervention which is gaining increasing currency in the area of violent behaviour, including sexual offending (Pithers 1990) and domestic violence (Jennings 1990). Given the situat...

BACKGROUND Lung cancer most often presents as an inoperable tumour and the diagnosis is usually performed on a small biopsy/cytology specimen. In the group of non small cell lung cancer - not otherwise specified, adenocarcinoma phenotype can be determined immunohistochemically using TTF-1 and Napsin A. Expression of oncofetal protein IMP3 in human cancer is associated with poor differentiation ...

A healthy policeman was prescribed bupropion in 2002 to help him stop smoking. It worked but after 18 months he relapsed. Though it had given him headaches and insomnia he tried using it again in 2009, [corrected] taking 150 mg/day. Three days after starting the tablets he took his wife out for dinner. They shared a bottle of wine and he also had other drinks. After walking home they quarrelled...