Two-dimensional infrared correlation spectroscopy (2D-IR) was used in this study to investigate the aggregation of cytochrome c in the presence of dimyristoylphosphatidylglycerol. The influence of temperature on the aggregation has been evaluated by monitoring the intensity of a band at 1616 cm(-1), which is characteristic of aggregated proteins, and the 2D-IR analysis has been used to determin...

Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...

Library and museum digital collections are increasingly aggregated at various levels. Large-scale aggregations, often characterized by heterogeneous or messy metadata, pose unique and growing challenges to aggregation administrators – not only in facilitating end-user discovery and access, but in performing basic administrative and curatorial tasks in a scalable way, such as finding messy data ...

Imbalance in metal ion homeostasis is a hallmark in neurodegenerative conditions involving protein deposition, and amyotrophic lateral sclerosis (ALS) is no exception. In particular, Ca(2+) dysregulation has been shown to correlate with superoxide dismutase-1 (SOD1) aggregation in a cellular model of ALS. Here we present evidence that SOD1 aggregation is enhanced and modulated by Ca(2+). We sho...

We demonstrate a microfluidic platform for the controlled aggregation of colloidal silver nanoparticles using surface acoustic waves (SAWs), enabling surface enhanced Raman scattering (SERS) analysis of oxidative damage in cells. We show that by varying the frequency and the power of the acoustic energy, it is possible to modulate the aggregation of the colloid within the sample and hence to op...

Social Choice Theory (SCT), and the study of collective methods for decision making in general, have received a lot of attention in the AI community in recent years. The reasons for this focus are clear: SCT provides tools for the analysis of collective choices of groups of agents, and as such is of immediate relevance to the study of multiagent systems. At the same time, studies in AI have led...

Aggregation is generally a time consuming process that is only marginally suited for interactive result exploration. This work presents a framework of techniques to support an extended aggregation that works online and is controllable by user feedback. Supportive visualisation methods are presented as well as an overview of applicable interaction techniques and a generic architecture combining ...

When tobacco is smoked, chewed or snuffed, nicotine is absorbed by the lungs or mucous membrane and quickly moved into the bloodstream, where it is circulated throughout the brain. In fact nicotine is highly dangerous to be consumed in any form. The present study was conducted to know the adverse effects of nicotine on the platelet aggregation in cerebral microvessels of mice. Male mice of aver...

We develop a new model for fuzzy decision making based on the use of several sources of information in the analysis. We introduce the fuzzy unified aggregation operator (FUAO). It is an aggregation operator that unifies other aggregation operators in the same formulation and considering the degree of importance of each concept in the analysis. Moreover, it also deals with uncertain environments...