Explanted mouse limb buds aged 12, 13 or 14 days cultured for 9 days in vitro failed to develop a marrow cavity or show endochondral ossification. Explants aged 15 days developed a marrow cavity and showed signs of endochondral ossification. The periosteum in these limbs was perforated and laminated and cells appeared to be passing between the laminae to populate the marrow cavity. This suggest...

In several species, resveratrol, a polyphenolic compound, activates sirtuin proteins implicated in the regulation of energy balance and biological clock processes. To demonstrate the effect of resveratrol on clock function in an aged primate, young and aged mouse lemurs (Microcebus murinus) were studied over a 4-week dietary supplementation with resveratrol. Spontaneous locomotor activity and d...

background: this study aimed to design a new mouse and evaluate some of its functional parameters. the prototype of an ergonomic mouse was made according to design principles. methods: the study was conducted from 2011 to 2013 in the department of ergonomics in shiraz university of medical science. functional parameters including movement time (mt) and error rate of the new mouse were evaluated...

Skeletal muscle regenerative potential declines with age, in part due to deficiencies in resident stem cells (satellite cells, SCs) and derived myogenic progenitors (MPs); however, the factors responsible for this decline remain obscure. TGFβ superfamily signaling is an inhibitor of myogenic differentiation, with elevated activity in aged skeletal muscle. Surprisingly, we find reduced expressio...

Human beings have always made their tools and instruments they need using patterns in nature. Mimicking nature has become the foundation of a new science called Biomimetics. In the present article, multiple forms and levels in nature were utilized to design and create a mouse. The rivers are a good source for choosing the shape of a mouse with lots of stones abraded through the centuries which ...

Background: The ability of polyclonal antibodies to react with many epitopes of an antigen makes them valuable reagents in research and diagnosis. The aim of this study was purification of mouse IgG2a and production of polyclonal antibody against purified mouse IgG2a subclass. Materials and Methods: Mouse IgG2a was purified by ProA affinity. Verification method of the purified antibody was S...

Ruffini nerve endings in the periodontal ligament (PDL) of aged mouse maxillary incisors were investigated by means of immunohistochemistry for protein gene product 9.5 (PGP 9.5) at light and electron microscopic levels. C3H/HeSlc mice were sacrificed by perfusion fixation. Frozen sagittal cryostat sections of decalcified maxillary incisors were prepared and stained by anti-PGP 9.5 antibody, fo...

However fundamental he may appear to us, the public prosecutor was an historical latecomer. Judge and jury we can trace back to the high Middle Ages. But the prosecutor became a regular figure of Anglo-American criminal procedure only in Tudor times. Further, his appearance then has not been noticed in our historical literature, an especially remarkable omission when we discover that the prosec...