REFLEX CONTROL OF cardiac function is dependent on the transduction of the sensory milieu in cardiac tissues and within major intrathoracic and cervical blood vessels. Transduction can involve mechanosensitive and/or chemosensitive inputs. Reflexes for the control of autonomic efferent outflows to the heart so engendered include the peripheral and central aspects of the cardiac nervous system. ...

The chordotonal organ at the femorotibial joint of a locust hind leg monitors extension and flexion movements of the tibia. During evoked or imposed movements of this joint the central terminals of afferent neurons from the chordotonal organ receive depolarizing, inhibitory synaptic inputs. The afferent spikes are therefore superimposed on these depolarizing IPSPs, which are generated indirectl...

We conducted morphometric studies on the afferent arteriole of spontaneous hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats to gain a better understanding of its changes with the development of hypertension. Differences may be related to the SHRs' increased renal vascular resistance. Methacrylate vascular casts were made of the renal vasculature after perfusion fixation with glutaraldehyde. ...

The production of cortical evoked potentials by large afferent volleys is a well documented phenomenon6,7,12,22, 24. Considerable evidence has been amassed that the maximal evoked response results from a small afferent volley in a single nerve (see e.g. ref. 18). In fact, Amassian 2 has calculated that activity in as few as 12 dorsal column fibers can produce the maximum cortical evoked respons...

Renganathan, M., T. R. Cummins, W. N. Hormuzdiar, and S. G. Waxman. a-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons. J Neurophysiol 84: 710–718, 2000. In this study, we used sensory neuron specific (SNS) sodium channel gene knockout (2/2) mice to ask whether SNS sodium channel produces the slow Na current (“slow”) in large (.40 mm diam) cutaneous aff...

There is evidence that the metabolic responses to afferent and efferent nervous activity are dissociated at sites of neuronal excitation in brain. Whether efferent activity follows afferent activity depends on the responsiveness of postsynaptic neurons, which in turn depends on the summation of excitatory and inhibitory postsynaptic potentials. The afferent activity excites the presynaptic term...

1. Afferent nerve fibres sensitive to changes in the renal chemical environment have been found in the rat. To verify the existence of these fibres in the rabbit and their response pattern, afferent renal nerve activity was recorded during pelvic perfusions with NaCl solutions at different concentrations. 2. The experiments were carried out in 13 anaesthetized rabbits. Arterial pressure from a ...

Proteinase-activated receptors (PARs) are a novel class of G protein-coupled receptors that respond to signals through endogenous proteinases. PAR activation involves enzymatic cleavage of the extracellular NH(2)-terminal domain and unmasking of a new NH(2) terminus, which serves as an anchored ligand to activate the receptor. At least four PAR subtypes have been identified. In the present stud...

Lymphocytes continually recirculate between the bloodstream, extravascular tissues, lymph nodes, and lymph (1) . This circulation ofcells could provide ameans whereby large numbers oflymphocytes with different antigen specificities mayencounter antigen, allowing specific antigen-reactive cells to be selected out and to accumulate at sites of antigen deposition . Lymphocytes leave the blood at p...