METHODS The in vitro activity of kinase inhibitors targeting mTOR (RAD001), EGFR, HER2/neu, VEGFR (AEE788) and IGF-1R (AEW541) alone or in combination with cisplatin was tested in the cisplatin sensitive TGCT cell lines H12.1 and GCT72 as well as in the resistant cell lines H12.1RA, H12.1D, 1411HP and 1777NRpmet using the sulforhodamin-B-(SRB)-cytotoxicity-assay. To evaluate the activity of the...

BACKGROUND Overexpression of the ERBB2 kinase is observed in about one-third of breast cancer patients and the dual ERBB1/ERBB2 kinase inhibitor lapatinib was recently approved for the treatment of advanced ERBB2-positive breast cancer. Mutations in the ERBB2 receptor have recently been reported in breast cancer at diagnosis and also in gastric, colorectal and lung cancer. These mutations may h...

As escolas regulares devem assegurar aos alunos surdos uma Educação Especial dentro da perspectiva inclusiva mediante o acesso ao Atendimento Educacional Especializado (AEE), bem como educação bilíngue na presença do Intérprete (IE). Diante destas preconizações legais, esta pesquisa baseou-se em um estudo de caso, abordagem qualitativa, cujo intuito foi analisar processo inclusão escolar e ensi...

The artificial freezing method is used to cross the water-rich soft rock strata in order exploit deep coal resources. At present, studies that consider both effect and unloading rate are insufficient. To study influences of excavation using on deformation failure surrounding rock, we carry out mechanical synchronous acoustic emission (AE) tests frozen (−10 °C) sandstone samples under different ...

A quasi-experimental study compared the effects of feedback condition on eighth-grade students’ writing motivation and writing achievement. Four classes of eighth-graders were assigned to a combined feedback condition in which they received feedback on their writing from their teacher and from an automated essay evaluation (AEE) system called PEGWriting®. Four other eighth-grade classes were as...