Metronidazole is a well-known antimicrobial agent, used for the treatment of anaerobic bacterial and protozoal infections. It generally well tolerated with common side effects like nausea, dizziness, headache metallic taste in mouth. But prolonged use metronidazole can cause neurotoxicity ataxic gait, dysarthria, seizures encephalopathy. Here, we are reporting case 60 years old male patient who...

Benzodiazepines may increase the risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes in patients 65 years older. The concomitant use benzodiazepines opioids also be inappropriate for older adults due to increased overdose. We searched Pennsylvania Patient Safety Reporting System (PA-PSRS) reports patient safety events related order gain a better understanding pot...

Objective: To report alopecia universalis (AU) as an adverse effect of adalimumab that has not yet been documented in literature. Case Summary: A 50-year-old male was diagnosed with psoriasis and psoriatic arthritis and was commenced on adalimumab subcutaneous injections biweekly. The psoriatic skin lesions and arthritis showed improvement. However, one year later he lost all his body hair incl...

PURPOSE The improvement and linkage of two Department of Veterans Affairs (VA) databases for monitoring adverse drug reactions (ADRs) are described, with a discussion of the potential implications for improved medication safety within the VA health care system. SUMMARY Before 2007, VA had limited capability to track and evaluate ADRs across its nationwide network of health care facilities. Si...

Adverse drug reaction (ADR) risk-prediction models for use in older adults have been developed, but it is not clear if they are suitable for use in clinical practice. This systematic review aimed to identify and investigate the quality of validated ADR risk-prediction models for use in older adults. Standard computerized databases, the gray literature, bibliographies, and citations were searche...

Background Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation Herein we present a case of 56-year-old male patient with no known history of recurrent nightmares and sleep disorder, experiencing nightmare and abnormal dreams directly after co...

This paper presents findings from case studies of health consumers who each suspect they may have experienced an adverse drug reaction (ADR). These case studies are part of a larger study involving consumer/doctor decisions surrounding suspected adverse drug reactions and prescribing. Decision support to assist with the diagnosis and management of ADRs has, to date, primarily focused on providi...

background: the most common types of medical error are medication errors (mes) which defined as any preventable event that may be caused by an inappropriate medication usage and lead to an adverse drug reaction (adr) event in patients. in recent years, different approaches have been proposed to reduce mes, one of which is reporting adrs. the present study was designed to assess the knowledge, a...

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and the perception of ADR associated with COX2-Inbitors, paracetamol, NSAIDs, and morphine in medical students and residents of northeast...

BACKGROUND The concomitant use of multiple medications by elderly patients with hypertension is a relatively common and growing phenomenon in Japan. This has been attributed to several factors, including treatment guidelines recommending prescription of multiple medications and a continuing increase in the elderly population with multiple comorbidities. OBJECTIVE This study was aimed at inves...