Our previous studies have shown that the cardiac sympathetic afferent reflex is enhanced in rats with chronic heart failure (CHF) induced by coronary artery ligation and contributes to the over-excitation of sympathetic activity. We sought to determine whether sympathetic activity and cardiac sympathetic afferent reflex were enhanced in adriamycin-induced CHF and whether angiotensin II (Ang II)...

Adriamycin cardiotoxicity is associated with oxidative stress in the presence of globally depressed cardiac function. It is unknown if there is a similar profile with early diastolic changes and how it relates to baroreflex control of circulation. In this study, we evaluated baroreflex control of circulation in adriamycin-treated Wistar rats compared with controls, using invasive blood pressure...

The principal goal of this study was to determine the effect of the photoperiod on oxidative damage biomarkers in rats submitted to different light/darkness patterns, in a hyperlipidemic nephropathy model (induced by adriamycin), as well as its possible relationship with melatonin and leptin secretion rhythms. To test this hypothesis, six different groups were used (N = 6 rats per group): contr...

Nephrotic syndrome is associated with resistance to the renal actions of atrial natriuretic peptide (ANP). We performed experiments in anesthetized, acutely nephrectomized rats 21-28 days after injection of adriamycin (7-8 mg/kg iv) or 9-14 days after injection of anti-Fx1A antiserum (5 ml/kg ip) (passive Heymann nephritis; PHN) to test whether extrarenal resistance also occurred. Proteinuria w...

We have investigated the effect of cellular fatty acid alteration on Adriamycin cytotoxicity using the L1210 lymphoblastic leukemia cell line. Cells growing in Roswell Park Memorial Institute Medium 1640 with 5% fetal bovine serum were modified with respect to fatty acid composition by supplementing their growth medium with 32 microM docosahexaenoic acid (22:6) or oleic acid (18:1). A soft agar...

Objective: To explore the reversal effects of triptolide (TP) on drug-resistance of adriamycin (Adriacin doxorubicin, ADR)-resistant human breast cancer cell lines (MCF-7/ADR) in vivo and in vitro. Methods: effects of triptolide and adriamycin on MCF-7 and MCF-7/ADR cell proliferation was measured by CCK-8, the reversal effect of triptolide on the drug-resistance of MCF-7/ADR cells was also mea...

This paper reviews the concept of absorptive capacity and its relationship to innovation management capability. It explores four key questions concerning definition, dimensions, distribution and development of AC and presents a model framework for examining policy interventions aimed at enhancing it. ‘Broadcast’, ‘agent assisted’ and ‘peer-assisted’ modes are discussed with reference to example...

Abstract Background and Aims Heparanase is an endo-β-d-glucuronidase that degrades heparan sulfate side chains, which are essential components of extracellular matrices cell surfaces, including in the kidney filtration apparatus, glomerulus. Upregulation heparanase glomerular diseases (GDs) was demonstrated experimental models GDs humans. Using transgenic mice overexpressing human gene, we rece...