The pulsatile release of cortisol from the adrenal glands is controlled by a hierarchical system that involves corticotropin releasing hormone (CRH) from the hypothalamus, adrenocorticotropin hormone (ACTH) from the pituitary, and cortisol from the adrenal glands. Determining the number, timing, and amplitude of the cortisol secretory events and recovering the infusion and clearance rates from ...

The stimulatory effects of epinephrine, glucagon, and adrenocorticotropin (ACTH) upon lipolysis and on the uptake and oxidation of glucose were studied in isolated rat epididymal adipocytes. Under conditions in which prostaglandin El (PGE1) and nicotinic acid were antilipolytic against epinephrine, these agents were without influence on the effects of the hormone on the metabolism of glucose. F...

Mast cells (MC) are hemotopoietically derived tissue immune cells that are ubiquitous in the body, including neuroendocrine organs such as the hypothalamus, pineal, pituitary, ovaries, pancreas and uterus where their action is not well understood. Mast cells have historically been associated with allergies because of their rich content of histamine and tryptase, but more recently with regulatio...

Dra. Antonia Mora, Calle Alicante, 51, E-03140 Guardamar del Segura, Alicante (Spain) Dear Sir, Hyponatremia is a complication of untreated hypopituitarism and has been associated with an inappropriately high secretion of antidiuretic hormone (ADH). Usually it is not severe and rarely becomes a major symptomatic problem [1]. We describe a patient with severe hyponatremia as the presenting featu...

Abstract Autoregulation of receptor systems by their own ligands is a well established biological phenomenon. While down-regulation of the glucocorticoid binding capacity by glucocorticoids has been shown in animals and humans, data on up-regulation processes in humans are lacking. To further explore glucocorticoid receptor plasticity in relation to endogenous ligands, glucocorticoid binding pa...

background beta-thalassemia is the most common hematology disease in human and leptin is one of the hormone that produce by adiposities cells. the purpose of this study was to investigate the relationship between serum leptin level and thyroid hormones in children with major beta-thalassemia. materials and methods this descriptive-cross sectional study was performed on 90 children aged 6-16 yea...

Stress activates several neural pathways. The main stress response systems are the locus coeruleus, sympathetic-adrenal medullary system, and the hypothalamic–pituitary–adrenal (HPA) axis (Zhang et al., 2005). Stressors stimulate the paraventricular nuclei of the hypothalamus, where corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are synthesized. CRH is a central component ...