precocious pubarche (pp) is most often a benign condition secondary to the early appearance of adrenarche. however, pp may be a manifestation of mild errors of steroidogenesis in particular non classic 21 hydroxylase deficiency (nc210hd). the incidence of nc210hd in patients with pp ranges from about 0-30% of cases in various reports. controversy exists as to whether all children with pp should...

background: precocious puberty, as early physical development and low final height might lead to psychosocial problems. objective: to evaluate etiology and clinical feature of precocious puberty in a cohort of iranian children. materials and methods: in this case-series study, 44 girls and 8 boys with precocious puberty referred to endocrine reserch centre (firouzgar), institute of endocrinolog...

21-hydroxylase deficiency (21-ohd) caused congenital adrenal hyperplasia (cah) is a group of autosomal recessive genetic disorders resulting from mutations in genes involved with cortisol (co) synthesis in the adrenal glands. testicular adrenal rest tumors (tarts) are rarely the presenting symptoms of cah. here, we describe a case of simple virilizing cah with tarts, in a 15-year-old boy. the p...

a four day old female infant was admitted because of poor feeding, vomiting and jaundice. laboratory examination showed hyperkalemia, mild hyponatremia and renal tubular acidosis type 4. serum aldosterone and plasma renin activity were elevated but serum cortisol, 17 -hydroxyprogesterone, acth, 24 hour urinary 17- ketoste roid, pregnanetriol, renal function and sonogram were normal and hence ps...

UNLABELLED Myxoedema madness was first described as a consequence of severe hypothyroidism in 1949. Most cases were secondary to long-standing untreated primary hypothyroidism. We present the first reported case of iatrogenic myxoedema madness following radioactive iodine ablation for Graves' disease, with a second concurrent diagnosis of primary hyperaldosteronism. A 29-year-old woman presente...

Congenital Adrenal Hyperplasia is a group of autosomal recessive disorders due to deficiencies enzymes involved in steroidogenesis. Clinical manifestations depend on the degree cortisol and aldosterone deficiency. The salt-wasting form can present as medical emergency with severe hyponatremic dehydration, hyperkalemia, polyuria hyperpigmentation. However, recent years, patients CAH presenting a...

An adrenal cortical cell rest, an interstitial cell, and a pleuripotent cell have all been suggested as the origin of testicular masses in congenital adrenogenital syndrome. 2 Embryologically the development of the adrenal gland and the genital ridge occurs in close proximity. Adrenal cell rests are therefore known to occur in the spermatic cord, testis, broad ligament, and the ovary. The norma...

An adrenal cortical cell rest, an interstitial cell, and a pleuripotent cell have all been suggested as the origin of testicular masses in congenital adrenogenital syndrome. 2 Embryologically the development of the adrenal gland and the genital ridge occurs in close proximity. Adrenal cell rests are therefore known to occur in the spermatic cord, testis, broad ligament, and the ovary. The norma...

An adrenal cortical cell rest, an interstitial cell, and a pleuripotent cell have all been suggested as the origin of testicular masses in congenital adrenogenital syndrome. 2 Embryologically the development of the adrenal gland and the genital ridge occurs in close proximity. Adrenal cell rests are therefore known to occur in the spermatic cord, testis, broad ligament, and the ovary. The norma...

The administration of cortisone to patients with virilism associated with adrenal hyperplasia results in a marked decrease in urinary 17-ketosteroid excretion (1-3) whereas no significant fall occurs in those patients whose virilism is due to an adrenal tumor (4, 5). The administration of cortisone inhibits pituitary adrenocorticotropin secretion causing secondary atrophy of the adrenals (6, 7)...