Adrenocorticotropin (ACTH) independent bilateral macronodular adrenal hyperplasia (AIMAH) is a rare cause of Cushing's syndrome, characterized by bilateral adrenal lesions and excess cortisol production despite ACTH suppression. Cortisol synthesis is produced in response to abnormal activation of G-protein-coupled receptors, such as gastric inhibitory peptide, vasopressin, beta adrenergic agoni...

OBJECTIVE To assess the feasibility and reliability of apparent diffusion coefficient (ADC) measurements of normal adrenal glands. MATERIALS AND METHODS This was a retrospective study involving 32 healthy subjects, divided into two groups: prepubertal (PreP, n = 12), aged from 2 months to 12.5 years (4 males; 8 females); and postpubertal (PostP, n = 20), aged from 11.9 to 61 years (5 males; 1...

I N 1891 Jacobi described nerves branching from the splanchnics ‘and supplying the adrenal gIands .I Six years later Biedl found that these nerves conveyed vaso-dilator impulses to the glands, and suggested that they probably conveyed also secretory impulses.2 Evidence for this suggestion was presented the following year by Dreyer, who demonstrated that electrical stimulation of the splanchnics...

I N 1891 Jacobi described nerves branching from the splanchnics ‘and supplying the adrenal gIands .I Six years later Biedl found that these nerves conveyed vaso-dilator impulses to the glands, and suggested that they probably conveyed also secretory impulses.2 Evidence for this suggestion was presented the following year by Dreyer, who demonstrated that electrical stimulation of the splanchnics...

Li XC, Zhuo JL. In vivo regulation of AT1a receptor-mediated intracellular uptake of [I]Val-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice. Am J Physiol Renal Physiol 294: F293–F302, 2008. First published November 28, 2007; doi:10.1152/ajprenal.00398.2007.—Using type 1a angiotensin receptor (AT1a) receptor-deficient (Agtr1a / ) mice and in vivo autoradiography, we tested the...

The microsomal enzyme acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) catalyzes the esterification of cellular cholesterol with fatty acids to form cholesterol esters. ACAT activity is found in many tissues, including macrophages, the adrenal glands, and the liver. In macrophages, ACAT is thought to participate in foam cell formation and thereby to contribute to atherosclerotic lesion ...

To determine the influence of colchicine on adrenocortical function in vivo, we gave significant amounts subcutaneously to rats and observed the distribution to the anterior pituitary and adrenal glands. Corticosteroids in the serum and adrenal gland were increased remarkably by the administration of colchicine in a dose-dependent manner. Maximum elevation was achieved around 2.5 hours after th...

BACKGROUND Adrenal crisis after surgical procedure is a rare but potentially catastrophic life-threatening event. Its manifestations, such as hypotension, tachycardia, hypoxia, and fever mimic the other more common postoperative complications. Clinical outcome is dependent upon early recognition of the condition and proper management with exogenous steroid administration. CASE PRESENTATION We...

OBJECTIVE To determine whether, during the staging of newly diagnosed bronchogenic carcinoma, clinical indicators predict the presence or absence of adrenal metastases detected by computerized tomographic (CT) scans. DESIGN Retrospective review of charts and roentgenograms. SETTING Academic medical center. PATIENTS Two hundred five consecutive patients diagnosed with bronchogenic carcinom...

Normal Anatomy of the Urinary Prune-Belly Syndrome/ 289 Tract/ 255 Megacystis-Microcolon-intestinal Bilateral Renal Agenesis/ 259 Hypoperistalsis Syndrome/ 291 Infantile Polycystic Kidney Congenital Mesoblastic Disease/ 266 Nephroma/ 292 Adult Polycystic Kidney Disease/ 268 Wilms’ Tumor/ 293 Multicystic Kidney Disease/ 270 Normal Anatomy of the Adrenal Ureteropelvic junction Glands/ 295 Obstruc...