The effect of inhaled corticosteroids (ICS) on the hypothalamic-pituitary-adrenal axis (HPA) has been regarded as a 'benign physiological response'. A recent survey suggests that adrenal crisis might be more common in asthmatic children on ICS than previously thought. The clinical features of adrenal insufficiency are non-specific and can easily be missed. Accurate biochemical assessment of the...

OBJECTIVES Adrenal insufficiency is often diagnosed by short synacthen test using intravenous Injection Synacthene, which is not marketed in India officially. To overcome this problem this study was planned to validate and use Acton Prolongatum (Ferring pharmaceuticals) as intramuscular ACTH stimulation test for evaluation of adrenal function. METHODS This study was planned in two groups. Fir...

In an attempt to elucidate the mechanism(s) through which the functional adrenal cortex is established, we analyzed immunohistochemically the expression of various markers for the adrenocortical zones, i.e. the zona glomerulosa (zG), the zona fasciculata (zF), and the zona reticularis (zR), as well as markers for the medulla, and further examined the distribution and behavior of DNA-synthesizin...

In man the essential functions of the adrenal cortex stem from at least two hormones, cortisol (hydrocortisone) and aldosterone, these differing in their quality of action, mode of secretory regulation, and probable site of production within the gland. The adrenal sex hormones are of relatively minor physiological importance and will not be considered here. The new synthetic analogues of cortis...

The three paired abdominal glands, the kidney, the suprarenal gland, and the gonad arise in the embryo from a common fold which later serves to retain the urinary and genital primordia to the dorsal body wall. It is well known that groups of adrenal cortical cells (which may originate as part of the suprarenal primordium) are often found quite distant to the location of the definitive suprarena...

1. The resistance of adrenal-deficient rats to bacterial intoxication has been significantly increased by an extract of the adrenal cortex. 2. This is shown both for acute intoxication with killed Bacillus typhosus and for chronic intoxication with killed Staphylococcus aureus. 3. During the height of the bacterial intoxication relatively large amounts of the cortical hormone are apparently req...

Modified synthetic N-POMC(1-28) without disulfide bridges has been shown to act as an adrenal mitogen. Cyclins and their inhibitors are the major cell cycle controls, but in the adrenal cortex the effect of ACTH and N-POMC on the expression of these proteins remains unclear. In this work, we evaluate the effect of different synthetic N-POMC peptides on the S-phase of the cell cycle. In addition...

The hormonal secretions of the adrenal cortex are known to be capable of causing a striking re gression of normal lymphoid tissue (cf. 22) and of exerting at least a transient growth-arresting ef fect on various types of lymphoid tumors (1, 2, 5, 6, 8, 12, 13, 20, 21, 24). In contrast, a selective action of corticosteroids on the metabolism of nor mal and malignant lymphoid tissue has not been ...