Type 2 diabetes mellitus (T2DM), which is characterized by insulin resistance and relative insufficiency, has become the most common chronic metabolic disease threatening global health. The preferred therapies for T2DM include lifestyle interventions use of anti-diabetic drugs. However, considering their adverse reactions, it important to find a low-toxicity effective functional food or drug pr...

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with still growing incidence among adults and young people worldwide. Patients T2DM are more susceptible to develop coronary artery (CAD) than non-diabetic individuals. Several pre-clinical clinical studies suggested that adiponectin, pleiotropic hormone anti-atherogenic, anti-inflammatory, insulin-sensitizing properti...

Physical inactivity is one of the major causes of type 2 diabetes, and exercise training contributes substantially to both the prevention and treatment of this disease. Physical exercise affects many biochemical characteristics of skeletal muscle and thereby influences energy metabolism of the whole body. Although the mechanism by which the biochemical properties of skeletal muscle adapt to phy...

Immune escape is a fundamental trait of cancer. Dendritic cells (DC) that interact with T cells represent a crucial site for the development of tolerance to tumor antigens, but there remains incomplete knowledge about how DC-tolerizing signals evolve during tumorigenesis. In this study, we show that DCs isolated from patients with metastatic or locally advanced breast cancer express high levels...