Hospitalized children are at greater risk for adverse drug events (ADEs) due to varying size, development and lack of pediatric specific dosing.The project determined ADE rate for40 randomly selected pediatric hospitalized inpatients utilizing the Pediatric-Focused Trigger Tool in a retrospective review. 171 triggers revealed 10 unique ADEs involving 8 patients, including ICU, general unit, and...

This study investigated the effects of homocysteine (Hcy) on angiogenesis in cultured human umbilical vein endothelial cells (HUVEC) and zebrafish embryos. We found that Hcy (50 micromol/L) significantly decreased cell numbers, viability, and induced a G1/S arrest in HUVEC in the presence of adenosine (Ade, 50 micromol/L). Hcy, in combination with Ade, reduced migration and suppressed tube-like...

DE algorithm is a population-based heuristic global search technology. The algorithm has simple principle, fewer control parameters, but has strong robustness, and good optimization performance. This paper uses differential evolution algorithm for parameters identification of Wiener model. Firstly, we analyze the influence of mutation rate F on global parallel search ability and convergence in ...

This paper introduces a new method that facilitates the stability analysis of system dynamics models. The method is based on the concepts of asymptotic stability and Accumulated Deviations from Equilibrium (ADE) convergence. We prove several theorems that show that ADE convergence of a state variable will make its trajectory approach asymptotic stability. Achieving ADE convergence requires the ...

A finite subgroup of the conformal group SL(2,C) can be related to invariant polynomials on a hypersurface in C. The latter then carries a simple singularity, which resolves by a finite iteration of basic cycles of deprojections. The homological intersection graph of this cycles is the Dynkin graph of an ADE Lie group. The deformation of the simple singularity corresponds to ADE symmetry breaki...

The complex-frequency-shifted perfectly matched layer CFS-PML technique can efficiently absorb near-grazing incident waves. In seismic wave modeling, CFS-PML has been implemented by the first-order-accuracy convolutional PML technique or second-order-accuracy recursive convolution PML technique. Both use different algorithms than the numerical scheme for the interior domain to update auxiliary ...

We describe an improved gel-based method with an additive Zn(2+)-cyclen complex (cyclen, 1,4,7,10-tetraazacyclododecane), Zn(2+)-cyclen-PAGE, for mutation detection in DNA fragments by PCR that contain more than 65% Ade/Thy bases and fewer than 100base pairs (bp). Existing techniques have a problem in analyzing such short Ade/Thy-rich fragments because the duplexes are disrupted and are not det...

Let Σ be a smooth projective complex curve and g a simple Lie algebra of type ADE with associated adjoint group G. For a fixed pair (Σ, g), we construct a family of quasiprojective Calabi-Yau threefolds parameterized by the base of the Hitchin integrable system associated to (Σ, g). Our main result establishes an isomorphism between the Calabi-Yau integrable system, whose fibers are the interme...

nature of Hex+Cxcr4+ (H+C+) ES cell derived ADE. Global expression analysis of ES cell derived ADE lead to the identification of an H+C+ gene expression cluster that contains well know anterior endoderm markers alongside a novel set of new sequence tags. Based on multiple pairwise comparisons between the H+C+ fraction and both differentiated and undifferentiated ES cell fractions, 66 genes were...

Extracellular adenosine (ADE) interacts with cells by two pathways: by activating cell surface receptors at nanomolar/micromolar concentrations; and by interfering with the homeostasis of the intracellular nucleotide pool at millimolar concentrations. Ade shows both cytotoxic and cytoprotective effects; however, the underlying mechanisms remain unclear. In the present study, the effects of aden...