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PURPOSE We examined whether inhibition of Src tyrosine kinase, a downstream effector of the MET oncogene, can hinder the malignant properties of gastric tumors dependent on Met for growth and survival. EXPERIMENTAL DESIGN Sensitivity to Src inhibition was determined in vitro by measuring clonogenic survival (anchorage-independent growth) and in vivo by establishing xenograft models. Four "Met...

Cocaine-induced acute hypertension is mediated largely by increased central sympathetic nerve activity. We hypothesized that dexmedetomidine, a central sympatholytic, reverses cocaine-induced increases in sympathetic nerve activity, mean arterial pressure (MAP), and heart rate (HR) in cocaine-addicted subjects. First, we conducted a dose-finding study in 15 nontreatment-seeking cocaine-addicted...

Rehabilitasyon, bir hastalık ya da kaza nedeniyle veya doğumsal olarak fiziksel ve ruhsal yetilerini yitirmiş olan bireyin eski sağlığını elde etmesini sağlamak var yeteneklerini güçlendirmek geliştirmek, fiziksel, ruhsal, psikolojik, sosyal ekonomik anlamda en üst kapasiteye ulaşabilmesi amacıyla gerçekleştirilen tüm faaliyetlerdir. Rehabilitasyon uygulamaları, kendi içerisinde, tıbbi rehabili...

A hypothesis about the neurobiological bases of drive, drive reduction and will in addictive illness is presented. Drive reduction seems to require both SEEKING and gratification. Will is the everyday term for our experience of drives functioning within us. Addictive drugs take over the will by altering neurotransmission in the SEEKING system. As a result of this biological change, psychologica...

Addiction to cocaine is a chronic condition characterized by high rates of early relapse. This study builds on efforts to identify neural markers of relapse risk by studying resting-state functional connectivity (rsFC) in neural circuits arising from the amygdala, a brain region implicated in relapse-related processes including craving and reactivity to stress following acute and protracted wit...

Background: Evidences show that parental morphine addiction impairs CNS development, learning and memory in offsprings. Since long term potentiation (LTP) is a cellular mechanism of learning and memory, in this study the effect of parental morphine addiction on LTP induction in dentate gyrus by high frequency stimulation of perforant path was assessed. Materials and methods: In this experiment...

Introduction: The problem of relapse makes addiction treatment complicated because almost 80% of addicts relapse after treatment completion during the first six months. The purpose of this study was to determine the factors affecting relapse in addicts referred to addiction treatment centers in Marand. Methods: This study was a cross-sectional study that was performed on 306 patients in the ci...