BACKGROUND AND PURPOSE Adenophostin A (AdA) is a potent agonist of inositol 1,4,5-trisphosphate receptors (IP(3) R). AdA shares with IP(3) the essential features of all IP(3) R agonists, namely structures equivalent to the 4,5-bisphosphate and 6-hydroxyl of IP(3) , but the basis of its increased affinity is unclear. Hitherto, the 2'-phosphate of AdA has been thought to provide a supra-optimal m...

OBJECTIVE Pleural effusion (PE) adenosine deaminase (ADA) has good performance in detection of tuberculous pleural effusion (TPE). However, few study was conducted for its value in pediatric patients. To evaluate PE ADA in diagnosis of pediatric TPE, a retrospective study was performed. PATIENTS AND METHODS 204 pediatric PE patients were enrolled, and then were grouped into TPE group (77 case...

This paper considers a class of switched dynamical systems to which two periodic inputs are applicable. We derive a one-dimensional (1-D) return map and its derivative analytically for arbitrary shapes of the inputs. Based on the derivative, we introduce a slope chart that displays the relationship between the slope of the return map and that of the inputs. Applying the slope chart to a simplif...

This paper presents a new software model designed for distributed sonic signal detection runtime using machine learning algorithms called DeLMA. A new algorithm--Acoustic Data-mining Accelerator (ADA)--is also presented. ADA is a robust yet scalable solution for efficiently processing big sound archives using distributing computing technologies. Together, DeLMA and the ADA algorithm provide a p...

To cite: Tanaka Y, Hirata S, Kubo S, et al. Ann Rheum Dis Published Online First: [please include Day Month Year] doi:10.1136/ annrheumdis-2013-204016 ABSTRACT Objectives To investigate the possibility of discontinuing adalimumab (ADA) for 1 year without flaring (DAS28erythrocyte sedimentation rate (ESR) ≥3.2), and to identify factors enabling established patients with rheumatoid arthritis (RA)...

OBJECTIVES To investigate the possibility of discontinuing adalimumab (ADA) for 1 year without flaring (DAS28-erythrocyte sedimentation rate (ESR) ≥3.2), and to identify factors enabling established patients with rheumatoid arthritis (RA) to remain ADA-free. METHODS Of 197 RA patients treated with ADA+methotrexate (MTX), 75 patients who met the ADA-free criteria (steroid-free and sustained DA...

during pregnancy within the specified time. Specifically, two in first trimester, once second and three third trimester. Currently, ANC visits are conducted by midwives to monitor development of mother fetus using MCH handbook.. During Covid-19 pandemic, an application is needed because can make it easier for pregnant women see their health development. This study aimed design Android-based Ant...

The purpose of this report is to provide technical input to the Deputy Assistant Secretary of the Air Force for Communications, Computers, and Logistics to assist that office in preparing a business case for using Ada or C++ to develop Corporate Information Management (CIM) systems. This technical input has been gathered by using the comparison methodology of a 1985 Federal Aviation Administrat...

abstract objective: it has been reported that adenosine deaminase (ada) is a good marker for insulin function but its clinical significance in type 2 diabetes mellitus (t2dm) is not yet characterized. this study aims to assess the association of ada with glycated hemoglobin (hba1c) and uric acid (ua) in t2dm patients. materials and methods: the study population consisted of 120 subjects divided...