The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH(2)-COOH or Heterar-CO-Se-CH(2)-COOH are reported. The synthesis was carried out by reaction of acyl chlorides with sodium hydrogen selenide, prepared in situ, and this led to the formation of sodium aroylselenides that subsequently reacted with alpha...

PARP-2 is a member of the poly(ADP-ribose) polymerase family, with some activities similar to those of PARP-1 but with other distinct roles. Two series of isoquinolin-1-ones were designed, synthesized, and evaluated as selective inhibitors of PARP-2, using the structures of the catalytic sites of the isoforms. A new efficient synthesis of 5-aminoisoquinolin-1-one was developed, and acylation wi...

The impacts of distribution water quality changes caused by blending different source waters on lead release from corrosion loops containing small lead coupons were investigated in a pilot distribution study. The 1-year pilot study demonstrated that lead release to drinking water increased as chlorides increased and sulfates decreased. Silica and calcium inhibited lead release to a lesser degre...

The relationship between melting temperature of multi-component chlorides and their ionic bond strength was studied. It can be used as a convenient method to know the when thermodynamic information is lacking for chlorides.

Background: N-Acyl homoserine lactone (AHL) is found to be the main component of quorum sensing (QS) in Gram-negative bacteria and plays an important role in biofilm formation. Little information is available regarding the role of AHL in biofilm formation in Escherichia coli (E. coli). The purpose of this investigation was to biochemically detect and characterize AHL activity in biofilm-forming...

soil-free rock rocks Introduction: Detection of elevated concentrations of S and Cl at the landing sites of Viking 1 and 2 [1], and Mars Pathfinder (MP) [2-5] reveals the presence of sulfates and chlorides in soil and rock samples [1-10]. These data are consistent with the findings of Ca sulfates and NaCl in Martian meteorites [11,12], and with Earth-based spectroscopic observations [13,14] ten...

In the st,udy of the plasma chlorides in a series of ncphritics Wolferth (1) recently called attention to the low figures occasionally obsc>rved in certain cases. As a rule, this finding was noted in patients lvho had been for some time upon a chloride-free diet This observation we (2) have confirmed and have found the plasma chlorides as low as 3.6 gm. per liter in one case of advanced glomcru...

The triterpene quassinoid ailanthinone is a structurally intricate natural product possessing highly potent antimalarial activity against multidrug resistance plasmodium parasites. Although the mechanism of action of ailanthinone is not completely understood, it is presumed to disrupt regular ribosomal functions by inhibiting parasite protein synthesis. Natural scarcity and low solubility of ma...

The triphenylstannyl p-u-glucopyranoside 4 was synthesized in one step from the 1.2-anhydro-a-uglucopyranose 3 with (hiphenylstannyl)lithium (Scheme 1) . Transmetallation of 4 with excess BuLi, followed by quenching the dianion 7 with CD,OD gave (1s)1 ,5-anhydro-3,4,6-tri-O-benzyl-f 1 -2H]-u-glucitol (8) in 81% yield (Scheme 2). Trapping of 7 with benzaldehyde, isobutyraldehyde, or acroleine ga...