background: in acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through dna methylation such as cdkn2b & p73. wnt inhibitory factor 1 (wif1) and dickkopf-3 (dkk-1) are negative regulators of wnt signaling pathway. in the present study, we evaluated the methylation status of wif1 and dkk-1 genes in acute myeloblastic leukemia patients. patients and methods: bloo...

Hematological disorders due to covid 19 infection are increasingly known hyperleukocytosis, lymphopenia and thrombocytopenia. However, the association between non-existent, non-apparent or asymptomatic acute leukemia remains rare. No causal relationship has been established leukemia. We report a case of young patient admitted for treatment severe viral pneumonitis in whom an was diagnosed.

Timely diagnosis and early initiation of treatment acute leukemia in children improve survival. Our study aimed to identify the factors associated with delayed children. A prospective observational was done at a tertiary care Superspeciality hospital Northern India. The included 100 aged 0–12 years over 18 months leukemia. A mixed-methods technique used, combining important variables...

associations of some hematological and lymphatic diseases with sex and abo and rh blood groups were studied in 2579 patients, compared with a control group of 126332 individuals, by the use of clinical as well as laboratory findings, in tehran. highly significant increase of male/female ratio is shown in acute myelogenous leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, aplas...

Evaluation the Effect of Chemotherapy Drugs and Thiosemicarbazone Complexes on Expression URHC CASC15 LncRNAs in Acute Lymphoblastic Leukemia Cell Line

Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...

A cancer diagnosis is one of the most difficult medical challenges. Leukemia a type that affects bone marrow and/or blood and accounts for approximately 8% all cancers. Understanding epidemiology trends leukemia critical planning. Specialists diagnose using morphological analysis, but there possibility error in diagnosis. Since so to diagnose, intelligent methods are required. The primary goal ...

Background. The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis–acute myeloid leukemia with myelodysplasia-related changes (≥20% myeloblasts of all nucleated cells) or myelodysplastic syndromes, and subdivides acute erythroid leukemia in...

Background: Serum lipids abnormalities have been observed in various forms of cancers including acute leukemia. Investigators report decreased total cholesterol and HDL, and elevated triglyceride in leukemic patients. Limited studies had been performed to discover the correlation between abnormal lipids profile and disease activity in leukemic patients in Iran. This study was done to evaluate t...

a 61-year-old female presented with complaints of fever, general weakness and hepatosplenomegaly. she had a history of nonfamilial peripheral neurofibromatosis diagnosed as von recklinghausen's disease since 30 years previous. physical examination was remarkable for skin colored cutaneous circumscribed nodules which appeared soft to the touch in both arms, the upper part of her abdomen, back, a...