Valuable clinical indicators for identifying infantile-onset inflammatory bowel disease patients with monogenic diseases

Sir, McNeill highlights in his Letter to the Editor that glucocerebrosidase (GBA) gene mutation carriers have reduced glucosylceramidase protein and enzyme activity based on measurements obtained from patient fibroblasts (McNeill et al., 2014). He links this to our data recently presented in Murphy et al. (2014) identifying similar findings in brain regions associated with increased a-synuclein...