The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...

The outer nuclear membrane is morphologically similar to rough endoplasmic reticulum. The presence of ribosomes bound to its cytoplasmic surface suggests that it could be a site of synthesis of membrane glycoproteins. We have examined the biogenesis of the vesicular stomatitis virus G protein in the nuclear envelope as a model for the biogenesis of membrane glycoproteins. G protein was present ...

The Friend virus causes a leukemia characterized by the early development of thrombocytopenia in the peripheral blood and by reticulum cell and erythroid hyperplasia in the spleen (6,8-11). Significant thrombocytopenia occurs 2 days after infection and is a major factor in the hemorrhagic disorder that results in the early death of affected animals (6). Approximately 3-4 days after infection, e...

Type I interferons (IFNs), pleiotropic cytokines with antiviral, antiproliferative, apoptotic, and immunoregulatory functions, are efficacious in the treatment of malignancies, viral infections, and autoimmune diseases. Binding of these cytokines to their cognate receptor leads to activation of the Jak-signal transducers and activators of transcription (STAT) signaling pathway and altered gene ...

introduction: we intended to assess the accuracy of re-expressed modification of diet for renal disease (mdrd) and cockcroft-gault (cg) equations to estimate glomerular filtration rate (gfr) in chronic kidney disease in two different etiologies of acute renal failure (arf): acute tubular necrosis (atn) and acute glomerulonephritis (agn). methods: patients admitted for arf or the patients compl...