An intravenous (i.v.) formulation of itraconazole was evaluated in disseminated fungal infection models in guinea pigs. In acute disseminated Candida albicans and Aspergillus fumigatus infections, treatment at 5 mg/kg of body weight twice a day (b.i.d.) significantly prolonged survival. In these models and in animals with chronic disseminated cryptococcosis, itraconazole given i.v. at 2.5 and 5...

UNLABELLED Fusarium spp. is an opportunistic mold that causes disseminated infections in immunocompromised patients. It is important to make a definite diagnosis because of high mortality rates. We present the case of a 27-year-old pregnant woman diagnosed with acute myeloid leukemia with a prolonged febrile neutropenic period. She developed ecthyma gangrenosum-like lesions and simultaneously h...

We studied the pathology of acute toxoplasmosis in experimental mice inoculated with RH strain tachyzoites of Toxoplasma gondii. All died from severe disseminated toxoplasmosis involving the liver, spleen and pancreas. Pathological features of acute toxoplasmosis in susceptible mice could be regarded as an excellent model for acute reactivation of Toxoplasma in the immunosuppressed host.

primary cardiac sarcomas are very rare and there is no consensus on management. clinical presentation is usually late. despite newer diagnostic technology, prognosis remains dismal. we report a case of right atrial sarcoma in a 28-year-old man who presented with acute cardiac tamponade. emergency subxiphoid pericardial drainage stabilized the patient's critical condition. the lesion was advance...

Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in...

ages; according to some authors more commonly young females. Pathologically the disease resembles disseminated sclerosis in that there is demyelinization of axis cylinders. The spinal cord shows such diffuse or multiple disseminated lesions. The optic nerves also present the same type of lesions. Clinically the disease is quite distinct from disseminated sclerosis. It is characterized by an acu...

Acute disseminated encephalomyelitis has been produced in rhesus monkeys by injection of their own brain tissue, removed surgically and incorporated with adjuvants.

OBJECTIVE Cerebrovascular disease (CVD) is a serious complication of acute leukemia, and the underlying conditions are different from the common risk factors for CVD. The aim of this study was to characterize the clinical and pathological features of CVD in patients with acute leukemia. PATIENTS OR MATERIALS In our series of 116 autopsied cases of acute leukemia during the period between Janu...

OBJECTIVE To date, no study has systematically investigated the impact of drowning-induced asphyxia on hemostasis. Our objective was to test the hypothesis that asphyxia induces bleeding by hyperfibrinolytic disseminated intravascular coagulation. DESIGN Observational study. SETTING A 2,100-bed tertiary care facility in Vienna, Austria, Europe. PATIENTS All cases of drowning-induced asphy...

Melioidosis is a potentially fatal infectious disease occurring predominantly in the tropics, caused by a Gram-negative, motile, rod shaped obligatory aerobic non-spore forming bacillus, Burkholderia pseudomallei. It can produce localised or disseminated disease largely affecting immunocompromised patients. It is a challenge to identify melioidosis early as this disease can manipulate host’s ce...