Deficiences imunitaire acquises Les , deficits nnmumtaires pathologiques af­ systeme des phagocytes, l'immunite a mechation_ cellulare :t la synthese des im­ Illfnoglobulmes so1t separement, soit con­Jom temen t. La manifestation .clinique de ces deficits est la ,frequence _des mfections bacterielles, vir­ales et mycotiques.  Le triteJent s deficits immunitaire a part la therap1e antnnfectieu...

We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, Re0, which measures the threshold for infection outbreak in a population that is not ...

Individuals exposed to Mycobacterium tuberculosis (Mtb) may be infected and remain for the entire life in this condition defined as latent tuberculosis infection (LTBI) or develop active tuberculosis (TB). Among the multiple factors governing the outcome of the infection, dendritic cells (DCs) play a major role in dictating antibacterial immunity. However, current knowledge on the role of the d...

The HER-2/neu oncogenic protein is a well-defined tumor antigen. HER-2/neu is a shared antigen among multiple tumor types. Patients with HER-2/neu protein-overexpressing breast, ovarian, non-small cell lung, colon, and prostate cancers have been shown to have a pre-existent immune response to HER-2/neu. No matter what the tumor type, endogenous immunity to HER-2/neu detected in cancer patients ...

Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled existence for millions years. Their lack acquired immunity sets marine apart from other animals. Invertebrates could rely on innate immunity, providing the first line defense, survival, thriving. The immune includes various biological...

Lupus vulgaris is a progressive form of skin tuberculosis occurring in the patients with a moderate to high degree of immunity. It is reported to be the commonest type of skin tuberculosis. Our case was a 40 year-old man who referred with multiple, erythematous, annular plaques, 30-50 mm in diameter with active margin and few studded pustules throughout the lesions. Our first impression was tin...

Trypanosoma cruzi infection is controlled but not eliminated by host immunity. The T. cruzi trans-sialidase (TS) gene superfamily encodes immunodominant protective antigens, but expression of altered peptide ligands by different TS genes has been hypothesized to promote immunoevasion. We molecularly defined TS epitopes to determine their importance for protection versus parasite persistence. Pe...

BACKGROUND Ageing, immunity and stresstolerance are inherent characteristics of all organisms. In animals, these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin-like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the ...

From 1981 through 1983, we did the first testing of cellular immunity in Lyme disease. Active established Lyme disease was often associated with lymphopenia, less spontaneous suppressor cell activity than normal, and a heightened response of lymphocytes to phytohemagglutinin and Lyme spirochetal antigens. Thus, a major feature of the immune response during active disease seems to be a lessening...