this research was conducted to study the effect of lime based flux with the composition of cao-20%caf2-8%feo on simultaneous removal of phosphorus and sulfur from hot metal. the effects of na2o and oxygen blowing were also studied. the experiments were performed using an induction furnace and hot metal produced in isfahan steel company in the temperature range 1350-1450 ºc. the results showed t...

A correlation is observed between changes in the level of Earth’s seismic activity and increments atmospheric methane concentration over past 40 years. Trigger mechanisms are proposed for emissions glacier collapse polar regions. These due to deformation waves caused by large earthquakes subduction zones located near regions: Aleutian Kuril–Kamchatka zones, closest Arctic, Antarctica–Chilean To...

Abstract We construct an anomaly-preserving compactification of 4D gauge theories, including SU(N) Yang–Mills theory, $\mathcal {N}=1$ supersymmetric and quantum chromodynamics (QCD), down to 2D by turning on the ’t Hooft flux through T2. This provides a new framework analytically calculate nonperturbative properties such as confinement, chiral symmetry breaking, multi-branch structure vacua. g...

Ship is an Src homology 2 domain containing inositol polyphosphate 5-phosphatase which has been implicated as an important signaling molecule in hematopoietic cells. In B cells, Ship becomes associated with Fcgamma receptor IIB (FcgammaRIIB), a low affinity receptor for the Fc portion of immunoglobulin (Ig)G, and is rapidly tyrosine phosphorylated upon B cell antigen receptor (BCR)-FcgammaRIIB ...

Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology. The development of biosensors then allowed measuring Rho GTPase activity with unprecedented spatio-temporal resolution. This revealed that Rho GTPase activity fluctuates on time and length sca...

The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incomplete...

Autophagy is an essential component of host immunity and used by viruses for survival. However, the autophagy signaling pathways involved in virus replication are poorly documented. Here, we observed that rabies virus (RABV) infection triggered intracellular autophagosome accumulation and results in incomplete autophagy by inhibiting autophagy flux. Subsequently, we found that RABV infection in...

Due to the existence of parallel pathways for receptor endocytosis and their complexities, a quantitative understanding of receptor endocytosis in normal and pathological settings requires computational analysis. Here, we develop a mechanistic model of epidermal growth factor receptor (EGFR) endocytosis to determine the relative contributions of three parallel pathways: clathrin-dependent inter...