Melanocytic nevi are among the most common benign human neoplasms and mimics, risk factors, potential precursors for melanoma. Many drivers of melanoma tumor progression have been identified, such as somatic mutations in RAS pathway genes. It is also known that germline genetic variants influence nevus count RASopathy patients. However, why develop certain undergo melanomagenesis remains largel...

Background: Recurrent nevus is a melanocytic lesion developing at the site of the removal of a previous benign nevus. While most cases are easily diagnosed with traditional histopathologic criteria, some cases have considerable histopathologic overlap with cases of regressed malignant melanoma. Objective: Clinical and histopathologic findings of recurrent nevi are compared to melanoma with regr...

Intense Pulsed Light (IPL) is a broadband visible light emitted from a non-coherent, filtered flashlamp. IPL sources emit light in the 500-1200 nm range and allow treatment of vascular and melanocytic lesions, and also hair removal. Different cutoff filters can be used to narrow the spectrum to target specific structures. 1 We report significant changes observed in two nevi after hair removal t...

Congenital melanocytic nevi (CMN) are defined as melanocytic nevi that present at birth or within the first few months of life. Small or medium-sized nevi occur in approximately 1% to 6% of all newborns, whereas giant nevi occur in approximately 1 in 20,000 [1-3]. There are two main considerations in the treatment of CMN. The first is predicting the risk of its transformation to melanoma, and t...

OBJECTIVES To identify in vivo microscopic substrates of the dermoscopic patterns of melanocytic lesions and to correlate them with histopathologic features. DESIGN Before excision, lesion areas that showed characteristic dermoscopic patterns were imaged by dermoscopy and confocal microscopy and directly correlated with histopathologic features. SETTING Departments of Dermatology of the Uni...

OBJECTIVE To evaluate with immunohistochemical methods 5 atypical melanocytic conjunctival lesions. METHODS This was a retrospective clinicoimmunopathologic study. Routine histochemical staining was performed with multiparametric immunohistochemical analysis with monoclonal antibodies immunoreacted on paraffin sections to identify the following cell antigens: S-100, MART-1, HMB-45, CD45, CD68...

In this week’s issue of PLOS Medicine, Jiali Han and colleagues [1] and Marina Kvaskoff and colleagues [2] describe prospective studies of melanocytic nevi and breast cancer risk among middle-aged women. Melanocytic nevi, commonly known as moles, are a heterogeneous group of benign tumors of the skin, which are commonly acquired in childhood and adolescence and which may disappear with increasi...