Acne vulgaris remains one of the most common diseases afflicting humanity and it is the skin disease most commonly treated by physicians.[1] It is a disease of the pilosebaceous units, clinically characterized by seborrhea, comedones, papules, pustules, nodules and, in some cases, scarring.[2] Although easy to diagnose, the polymorphic nature of acne vulgaris and its varied extent of involvemen...

resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we als...

BACKGROUND Acne is a common chronic inflammatory dermatosis of the pilosebaceous unit. It is characterized by seborrhoea, comedone formation and an inflammatory response consistent with defective cellular immunity to Propionibacterium acnes. OBJECTIVES The objective of this study was to investigate the immune reactivity of patients with acne compared with healthy controls by examining the res...

Background: So far seven types of the genus malassezia have been known. Except for one kind, the rest are normal flora of human skin, which under certain circumstances, cause or trigger eleven diseases. One of the side effects of topical and systemic steroid is steroid acne. Objective: This study was conducted to evaluate the association of pityrosporum ovale (Malassezia) and steroid acne...

Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two microorganisms involved in the pathogenesis of acne. In contrast, production ...

Acne vulgaris is a disease associated with sebaceous follicle. It starts appearing after the onset of puberty and can extend up to 40-50 years of age. As far as the pathogenesis of acne is concerned, it is not fully understood up till now. Treatment of acne is very frustrating and involves an understanding of etiopathological factors. This review focuses on various factors accountable, pathogen...

background acne vulgaris is a multifactorial disease of the pilosebaceous unit. malassezia furfur is one of the causative agents of the disease.it provides a proper environment for propionibacterium to grow. miconazole inhibits the propionibacterium growth by its fungicidal activity. objectives the aim of this study was to evaluate the treatment of acne vulgaris using the combination of topical...

Proliferation of follicular keratinocytes Knaggs H, Holland K, Morris C, Wood E, Cunliffe W. Quantification of cellular proliferation in acne using the monoclonal antibody Ki67. J Invest Dermatol 1994;102:89-92. Keratinocyte proliferation was assessed in normal follicles and acne follicles by using the antibody Ki-67. Cellular proliferation was greater in normal follicles from acne-affected are...

OBJECTIVE To evaluate the association of growth hormone (GH), and insulin-like growth factor-1(IGF-1) in the production of male sex hormones and the severity of acne in Iraqi male patients, and to assess their role in development of secondary hyperlipidemia in such patients. METHODS We conducted this case-control study and single-center measurement of hormones and selected biochemical param...

OBJECTIVE: The objective of this selective EBM review is to determine whether or not dapsone gel is safe and effective for the treatment of acne vulgaris. STUDY DESIGN: A review of three English language studies published in 2007. Includes two randomized, double-blind, controlled trials and one open label, noncomparative study. DATA SOURCES: Randomized, controlled trials comparing dapsone gel t...