3-Methylcyclohexanone is only partially resolved by crystallisation with a chiral diol host compound (ee 40%), but when recrystallised from an equimolar mixture of the chiral diol host and a similar but achiral host we obtain complete resolution. The latter host acts as a nucleation inhibitor and the enhanced resolution is attributed to kinetic effects.

A highly stereoselective [2,3]-sigmatropic rearrangement of sulfur ylide generated through Cu(I) carbene and allyl and propargyl sulfides by a double asymmetric induction approach that combines a chiral camphor sultam auxiliary and Cu(I) catalyst with chiral or achiral diimine ligands has been developed.

A new chiral open-framework cobalt phosphite [C6N2H14][Co(HPO3)2] (1) with helical channels has been synthesized under solvothermal conditions in the presence of achiral organic amine. The circular dichroism (CD) spectrum indicates that the bulk crystals have optical activity. Magnetic measurements reveal that 1 is a weak ferromagnet.

A new method for effecting catalytic enantioselective intramolecular [5 + 2] cycloadditions based on oxidopyrylium intermediates is reported. The dual catalyst system consists of a chiral primary aminothiourea and a second achiral thiourea. Experimental evidence points to a new type of cooperative catalysis with each species being necessary to generate a reactive pyrylium ion pair that undergoe...

We have considered chiral-achiral phase transitions that can occur in some liquid crystals. This study deals with such transformations induced by external electric and magnetic fields. We discuss phase changes mediated by disclinations, single solitons, soliton lattices and those occurring without any defect. Some unusual aspects ofthese transitions such as reentrance, occurrence of tricritical...

The first fluorescent hemicryptophane cage was synthesized and developed as an efficient and selective sensor for choline phosphate. The heteroditopic character of the host in the recognition process was evidenced. NMR experiments highlight a full encapsulation of the guest, inducing the chiralisation-like behavior of the achiral choline phosphate.

Several specific synthetic protocols were developed for the preparation from cyanuric chloride of a range of symmetric and non-symmetric di- and tri-substituted 1,3,5-triazines containing alkyl, aromatic, hindered, chiral and achiral hydroxyalkyl, ester and imidazole groups via sequential nucleophilic substitution of the C-Cl bond by C-O, C-N and C-S bonds.

We designed a planar chiral two-layered cyclophane, which is inherently achiral but desymmetrized by the arrangement of two nonstereogenic centers. We demonstrate the control of dynamic helicity that is generated by the helical twisting of two-layered planes in the cyclophane, where methyl and cyclohexylmethyl groups act as directing groups.

We report the development of a catalytic method for the enantioselective addition of indoles to pyrone-derived electrophiles. Arylpyrrolidino-derived thioureas catalyze the addition with high stereoselectivity in the presence of catalytic quantities of an achiral Brønsted acid. The indole-pyrone adducts feature a quaternary stereocenter and represent an unusual class of indolines bearing struct...

The achiral planar (maximum deviation 0.014 Å) title compound, C(10)H(6)Cl(2)O(2), crystallizes in the chiral space group P2(1)2(1)2(1) in an arrangement incorporating conventional O-H⋯O hydrogen bonding leading to a supra-molecular chain.