Acetylcholinesterase (AChE) inhibitors are widely used in Alzheimer’s treatment, but they also crucial for their action on organophosphorus insecticides. The latter exert toxicity by inhibiting the AChE enzyme insects, leading to death. Amaryllidaceae alkaloids have been proven be potent inhibitors. In present study methanolic extracts and essential oils being obtained from species of Asteracea...

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data used to determine structure compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability inhibit acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) en...

The evoked effects of the negatively charged drugs phenobarbital and barbituric acid, the positively charged imipramine, perphenazine and trifluoperazine, and the neutral primidone, on the synaptosome-associated acetylcholinesterase activity were studied. A marked increase in the enzyme activity was exhibited in the presence of low concentrations (up to 3 mM) of phenobarbital, barbituric acid a...