In this paper, we consider smooth convex optimization problems with simple constraints and inexactness in the oracle information such as value, partial or directional derivatives of the objective function. We introduce a unifying framework, which allows to construct different types of accelerated randomized methods for such problems and to prove convergence rate theorems for them. We focus on a...

We previously demonstrated that the utilization of an electrospun scaffold could boost functional outputs of transplanted islets. In this study, we aim to develop a drug-eluting scaffold with a payload of pioglitazone to simultaneously rein in hyperglycemia and recoup lost renal functions in diabetic mice that underwent islet transplantation. The in vivo proliferation of islets was measured by ...

Abstract Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in fate-specification step has been reported, mechanisms and key regulators underlying accelerated proliferation astrocyte precursor cells (APCs) DS remain elusive. Here, we established human isogenic cell line panel based DS-specific induced pluripotent stem ...

BACKGROUND The accelerated proliferation of vascular smooth muscle cells (VSMCs) is a contributor for atherosclerosis by thickening the vascular wall. Since zinc modulation of VSMC proliferation has not been clarified, this study investigated whether zinc affects VSMC proliferation. METHODS AND RESULTS Both a rat aorta origin vascular smooth muscle cell line (A7r5 VSMCs) and primary VSMCs whi...

5.9 million children under age five died in 2015, 16 000 every day. Globally, under-five mortality rate has decreased by 53%, from an estimated rate of 91 deaths per 1000 live births in 1990 to 43 deaths per 1000 live births in 2015. The average annual rate of reduction in under-five mortality has accelerated from 1.8%  a year over the period 1990–2000 to 3.9%  for 2000–2015 , but remains insuf...

The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...