BACKGROUND Canine pemphigus foliaceus is an autoimmune antibody-mediated skin disease characterized by acantholysis. The objective of this case report is to present the successful management of steroid refractory pemphigus foliaceus with cytotoxic T-lymphocyte antigen 4 (CTLA4)-overexpressing adipose tissue mesenchymal stem cells (ATMSCs). CASE PRESENTATION A 10-year-old, 12.3-kg, castrated m...

There are two major clinical subsets of pemphigus vulgaris (PV)-mucosal PV (mPV) and mucocutaneous PV (mcPV). The mPV subset exhibits anti-human desmoglein (Dsg) 3 autoantibodies that fail to recognize murine Dsg3 (mDsg3); thus, passive transfer experiments of mPV IgG into wild-type (WT) mice have been unsuccessful at inducing disease. We therefore generated a fully humanized Dsg3 (hDSG3) murin...

VOLUME 97, MARCH 2016 E1 WWW.CUTIS.COM To the Editor: The term pemphigus describes a group of autoimmune blistering diseases that are histologically characterized by intraepidermal blisters caused by acantholysis. There are several types of pemphigus foliaceus, such as classic and endemic pemphigus foliaceus, pemphigus erythematosus, pemphigus herpetiformis, and drug-induced pemphigus foliaceus...

PURPOSE To describe the pathophysiological findings of a patient with pemphigus vulgaris (PV) showing giant conjunctival papillae. METHODS A 64-year-old man who had mucosal-dominant PV with giant conjunctival papillae, resembling those of vernal keratoconjunctivitis (VKC), underwent an ophthalmological workup. The clinical and pathological findings were investigated. RESULTS Ophthalmic inte...

A 45-year-old white man with a medical history that was remarkable for human immunodeficiency virus and AIDS complicated by Kaposi sarcoma presented with a 14-year history of a recurring scaly, pruritic lesion on the dorsal aspect of his left shin. The lesion was refractory to treatment with topical corticosteroids, tazarotene, salicylic acid, and various emollient and keratolytic creams. Recen...

Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study we have measured ESR and CRP levels in patients with PV to evaluate the relationship between an ...

Pemphigus vulgaris (PV), a severe mucocutaneous blistering disease, results from autoantibody-mediated destabilization of epidermal cell-cell adhesion. A functional risk variant at the ST18 locus was found to promote expression. Increased expression aggravate deleterious effect PV autoantibodies in part through induction p53-mediated pro-apoptotic pathways. Global RNA sequencing human keratinoc...

Background: One of the controversies in treatment Pemphigus Vulgaris (PV), is time cessation. Scalp involvement often most stubborn to human area and may reflect disease activity. Trichoscopy (Dermoscopy hair scalp) features have not been studied clinically “healthy-looking” skin PV patients full remission. Aims Objectives:To find out if there are any trichoscopy clinical immunologic remission,...