Paradoxical absence of a pro-thrombotic phenotype in a Mouse model of severe hyper-homocysteinemia. The study by Eğin and Akar [1] entitled, First observation of MTHFR 678C-A (Ala 222 Ala) single nucleotide polymorphism, in the recent issue of the Journal (2012; 29: 204-5) requires questioning its importance to thrombosis in the light of Dayal et al.'s findings in a mouse model [2]. I used to t...

The environmental factors are considered to have a very important role in the development of different types of carcinoma (1,2). Among them, the nutritive factors containing initiators and promoters of carcinogenesis or acting as genotoxic carcinogens are of special importance. On the other hand, some nutritive deficiencies may influence the appearance of malignant diseases (3,4). Therefore, Ma...

In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine ((3-Acp)Ala) and 3-(trans-2’-nitrocyclopropyl)alanine ((3-Ncp)Ala) are originated via two homologous proteins, BelK HrmI, which regioselectively catalyze N?-oxygenation l-lysine. The enzymes belong to emerging heme-oxygenase-like diiron oxidase oxygenase (HDO) superfamily catalytic center is va...

To further examine the structural and thermodynamic basis of hydrophobic stabilization in proteins, all of the bulky non-polar residues that are buried or largely buried within the core of T4 lysozyme were substituted with alanine. In 25 cases, including eight reported previously, it was possible to determine the crystal structures of the variants. The structures of four variants with double su...

statement of problem: considering the importance of the occlusal plane orientation in complete denture prostheses, a study was conducted on the relationship between this plane with ala-tragus and camper’s lines in soft tissue among individuals with class iii malocclusion, in mashhad school of dentistry. purpose: the aim of the present study was to define the best soft tissue index by which the ...