It is well known that pure absence epilepsy is a benign form of seizure disorder, while most others, particularly partial and convulsive seizures may have transient or permanent deleterious consequences and are more difficult to bring under therapeutic control by anticonvulsants. The hypothesis is proposed that the preservation of GABA-ergic inhibition in absence attacks and its breakdown in mo...

A theorem of W. Kohnen states that the generalized Riemann hypothesis (GRH) holds on an average for holomorphic cusp forms on the upper half plane for the full modular group SL2(Z). In this article we prove a couple of generalizations of this theorem of Kohnen that the GRH holds on an average for holomorphic cusp forms on the upper half plane for arbitrary level, weight and primitive nebentypus...

Subclinical seizures (SCS) have rarely been considered in the diagnosis and therapy of epilepsy and have not been systematically analyzed in studies on seizure prediction. Here, we investigate whether predictions of subclinical seizures are feasible and how their occurrence may affect the performance of prediction algorithms. Using the European database of long-term recordings of surface and in...

Absence seizures are the most pure form of generalized epilepsy. They are characterized in the electroencephalogram by widespread bilaterally synchronous spike-wave discharges (SWDs), which are the reflections of highly synchronized oscillations in thalamocortical networks. To reveal network mechanisms responsible for the initiation and generalization of the discharges, we studied the interrela...

Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge-basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of abse...

Absence epilepsy is an important epileptic syndrome in children. Multiscale entropy (MSE), an entropy-based method to measure dynamic complexity at multiple temporal scales, is helpful to disclose the information of brain connectivity. This study investigated the complexity of electroencephalogram (EEG) signals using MSE in children with absence epilepsy. In this research, EEG signals from 19 c...

Sir, We read with interest the article by Asadi-Pooya et al. who reported a cross-sectional retrospective study comparing the demographic and electroclinical data of 30 patients with newly diagnosed typical childhood absence epilepsy (CAE) and 16 with newly diagnosed early-onset CAE (i.e., absence seizures starting before 4 years of age). The differences between the two groups with regard to se...