Although ABO incompatibility between mother and the conceptus has long been suspected as a cause of spontaneous abortion in man its precise contribution has not been completely resolved (Levene and Rosenfield, 1961). In spite of reports in which the incompatible mating was recognized to be a cause ofhabitual abortion (McNeil et al, 1954) and which eventually results in infertility (Behrman et a...

Background: Hyperbilirubinemia is a common problem in neonates. It is observed during the first week of the life in approximately 60% of term and 80% of preterm neonates. Kernicterus is a rare but serious consequence of undiagnosed hyperbilirubinemia. In this situation, indirect bilirubin deposit in the brain and causes transient dysfunction and occasionally permanent neuronal damage. The aim o...

AIM To avoid desensitization protocols and ABO incompatible kidney transplantation (KT) due to high costs and increased risk of infections from intense immunosuppression. METHODS We present institutional ethical review board - approved study of single center 6-way kidney exchange transplantation. The participants comprised ABO incompatibility (n = 1); positive cross-match and/or presence of d...

The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date. Whether this recurrence of A and B antigens is the result of an ancient polymor...

With estimates of the fitnesses of the genotypes and selection by incompatibility for the ABO locus which seem reasonable given the state of knowledge, a computer model has been developed to replicate the clines of the A and B genes in Europe. With a fitness change in the BB and BO genotypes of as little as 0.5%, the differences in the frequencies in East and West Europe can be maintained at eq...

Desensitization strategies for ABO-incompatible renal transplants with plasma exchange (PE) or specific immunoadsorption (IA) decrease immunoglobulin levels. After recent measles outbreak and decreasing vaccination rates, we studied the impact of apheresis on anti-measles antibodies. Anti-measles antibodies were measured before desensitization, before transplantation and during followup in 12 p...

BACKGROUND Situs inversus is a rare congenital anomaly characterized by the complete inversion of thoracic and abdominal organs. Liver transplantation in such patients or from donors in situs inversus is technically challenging because of the reversed anatomic structures. A small number of successful liver transplantation cases concerning situs inverus in either recipients or donors have been r...

Whether the coexistence of anti-A/B antibody and donor specific anti-HLA antibody (HLA-DSA) has a synergistic impact on the development of acute antibody-mediated rejection (AAMR) in kidney transplant recipients (KTRs) is unclear. This study includes 92 KTRs who received a kidney from an ABO-incompatible (ABOi) donor or were presensitized to donor HLA (HLAs) and 292 controls (CONT). HLAs was de...

BACKGROUND AND OBJECTIVES Blood incompatibility arises from individual and ethnic differences in red blood cell (RBC) antigen profiles. This underlines the importance of documenting RBC antigen variability in various ethnic groups. Central Asia is an area with a long and complex migratory history. The purpose of this article is to describe key antigen frequencies of Afghan ethnic groups in the ...