The enantioselective synthesis of advanced tetracyclic precursors of madangamine D, bearing rings ABCD of this alkaloid, is reported. The saturated 14-membered ring is assembled from functionalized diazatricyclic intermediates following either ring-closing metathesis or macrolactamization strategies.

Malignant melanoma is nowadays one of the leading cancers among many white-skinned populations around the world. Malignant melanoma, the most deadly form of skin cancer, has a good prognosis if treated in the curable early stages. Early diagnosis is the most effective treatment of melanoma. Well-trained dermatologists reach a high level of diagnostic accuracy but their performance is increased ...

In the framework of the paraxial approximation, the analytical expression of a family of Hypergeometric-Gaussian beams type-II passing through a paraxial ABCD optical system with a circular annular aperture is derived by means the expansion of the hard aperture function into a finite sum of complex Gaussian functions and using the generalized Huygens-Fresnel diffraction integral. Based on the o...

In this paper the development of a new internet information system for analyzing and classifying melanocytic data, is briefly described. This system also has some teaching functions, improves the analyses of datasets based on calculating the values of the TDS (Total Dermatoscopy Score) (Braun-Falco, Stolz, Bilek, Merkle, & Landthaler, 1990; Hippe, Bajcar, Błajdo, Grzymała-Busse, Grzymała-Busse,...

Recent advances in sequencing technologies have revolutionized genetic studies. Although high-coverage sequencing can uncover most variants present in the sequenced sample, low-coverage sequencing is appealing for its cost effectiveness. Here, we present AbCD (arbitrary coverage design) to aid the design of sequencing-based studies. AbCD is a user-friendly interface providing pre-estimated effe...

BACKGROUND AND PURPOSE A transient ischemic attack (TIA) is a brief ischemic episode characterized by rapid clinical resolution and not associated with permanent cerebral infarction. Whether changes in intracortical excitability persist and are related to clinical predictors of stroke risk after TIA remains unknown. METHODS Participants were individuals with clinically resolved motor TIA with...

BACKGROUND AND PURPOSE In patients with a recent TIA or minor stroke, prediction of long-term risk of major vascular events is important, but difficult. We aimed to study the external validity of currently available prediction models. METHODS We validated predictions from 3 population-based models (Framingham, SCORE, and INDIANA project) and 4 stroke cohort-based models (Stroke Prognosis Inst...

Using C4.5, a Data Mining System Ron Andrews Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045, USA Stanislaw Bajcar Regional Dermatology Center, 35-310 Rzeszow, Poland Jerzy W. Grzymala-Busse Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045, USA and Institute of Computer Science Polish Academy ...