نتایج جستجو برای: abcb11
تعداد نتایج: 428 فیلتر نتایج به سال:
PURPOSE Medical training spans nearly a decade, during which many physicians traditionally begin families. Although childrearing responsibilities are shared by men and women in the modern era, differences in time allocated to child care by sex and its potential impact on residency experience merit discussion. METHODS AND MATERIALS An anonymous, voluntary, 102-item survey was distributed to 54...
OBJECTIVES We describe observed improvements in nontechnical or "higher-order" deficiencies and cognitive performance skills in an anesthesia residency cohort for a 1-year time interval. Our main objectives were to evaluate higher-order, cognitive performance and to demonstrate that simulation can effectively serve as an assessment of cognitive skills and can help detect "higher-order" deficien...
Background and Aim: Progressive familial intrahepatic cholestasis (PFIC) refers to a heterogeneous group of liver disorders childhood which have hepatocellular origin. Largely, there are three distinct forms PFIC- 1,2 3 due increased access genetic studies, this list has expanded with newer mutations genes being discovered each day. Our study aims contribute the sparse existing literature varia...
Background and Aim: Progressive familial intrahepatic cholestasis (PFIC) vary from infantile onset severe disease to intermittent episodes of jaundice pruritus. Mutations display wide racial geographical variations hence data west cannot be extrapolated Indian population. This study was planned describe the spectrum mutations in children evaluate genotype-phenotype co-relation. Methods: is an o...
Although data are available on the change of expression/activity of drug-metabolizing enzymes in liver cirrhosis patients, corresponding data on transporter protein expression are not available. Therefore, using quantitative targeted proteomics, we compared our previous data on noncirrhotic control livers (n = 36) with the protein expression of major hepatobiliary transporters, breast cancer re...
Progressive familial intrahepatic cholestasis (PFIC) refers to a heterogeneous group of autosomal-recessive disorders of childhood that disrupt bile formation and present with cholestasis of hepatocellular origin. The exact prevalence remains unknown, but the estimated incidence varies between 1/50,000 and 1/100,000 births. Three types of PFIC have been identified and associated with mutations ...
mediciNe & HealtH/RHode iSlaNd the long-term objeCtIve of our reSearCh program is to understand how bile acid homeostasis is regulated in physiological as well as pathological conditions, with a focus on the transcriptional regulation of the bile salt export pump (BSEP). As one of the major constituents of bile, bile acids were once considered bodily waste with no useful functions. Now it is we...
Tissue-specific expression of transporters is tightly linked with their physiological functions through the regulation of the membrane transport of their substrates. We hypothesized that epigenetic regulation underlies the tissue-specific expression of mouse liver-specific transporters (Oatp1b2/Slco1b2, Ntcp/Slc10a1, Bsep/Abcb11, and Abcg5/g8). We examined their DNA methylation and histone modi...
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