Lactate acidosis due to mitochondrial toxicity has been particularly associated with stavudine and didanosine, but has also been reported in regimens with nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), which are considered to have less mitochondrial toxicity.1,2 Lactate acidosis presents with malaise, nausea, vomiting, fatigue, tachypnoea, liver involvement, and dysrythmia, and...
